Diabetes mellitus, periodontal disease Nutritional, Metabolic, Endocrine Unspecified diabetes mellitus
Conditions
Interventions
Periodontal treatment will include non-surgical scaling and root planing, systemic antibiotherapy, oral health instructions and antiseptic prescription. It will be performed within 10 days after inclu
Sponsors
University Hospital of Toulouse (CHU de Toulouse) (France)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or female, aged >= 18 year old 2. Diabetes mellitus (type I or II), diagnosed since at least one year 3. HbA1c levels comprised between 7.0 and 9.5% 4. No change in diabetic medication 3 months before inclusion 5. Periodontal disease (at least one site on at least 4 teeth with Probing Pocket Depth >= 4 mm AND Clinical Attachment Loss >= 3 mm) 6. At least 6 remaining teeth 7. Subject able to understand and willing to provide written informed consent in French 8. Subject affiliated to the security system
Exclusion criteria
Exclusion criteria: 1. Receiving antibiotherapy or chronic steroid therapy 2. Presence of significant renal disease, as indicated by creatinine clearance less than 60 ml/min 3. Have another medical condition likely to cause hospitalisation within 4 months 4. Presence of serious or unstable infectious disease, hepatic disease, phenylcetonuria 5. Subject at risk of endocarditis 6. Pacemaker 7. Antithrombotic treatment 8. History of allergy to amoxicillin and clindamycin 9. Pregnant, lactating, or plans to become pregnant during the study 10. Participation in another study with an investigational compound
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between 3-month and baseline HbA1c levels. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference between 3-month and baseline values of the following: 1. Fructosamin levels 2. Quality of life (SF-36® Health Survey) 3. Adverse clinical outcome event 4. Periodontal Inflamed Surface Area (PISA) | — |
Countries
France
Outcome results
None listed