Promoting Activity, Independence and Stability in Early Dementia and Mild Cognitive Impairment 2

Conditions

Dementia, mild cognitive impairment Mental and Behavioural Disorders

Kodchawan Doungsong, Ned Hartfiel, John Gladman, Rowan Harwood, Rhiannon Tudor Edwards

INQUIRY The Journal of Health Care Organization Provision and Financing2024-01-012 citations

Promoting Activity, Independence, and Stability in Early Dementia and mild cognitive impairment (PrAISED): randomised controlled trial

Rowan Harwood, Sarah Goldberg, Andrew Brand, Veronika van der Wardt, Vicky Booth et al. (40 authors)

BMJ2023-08-2935 citations

10.1136/bmj-2023-074787

Impact of COVID-19 lockdown on physical exercise among participants receiving the Promoting Activity, Independence and Stability in Early Dementia (PrAISED) intervention: a repeated measure study

Claudio Di Lorito, Veronika van der Wardt, Rebecca F. O’Brien, John Gladman, Tahir Masud et al. (6 authors)

BMC Geriatrics2022-07-219 citations

10.1186/s12877-022-03239-5

Estimating the minimum important difference in the DEMQOL instrument in people with dementia

Ellen Lee, J. Timothy Wright, Stephen J. Walters, Cindy Cooper, Gail Mountain

Quality of Life Research2021-06-109 citations

10.1007/s11136-021-02900-7

Protocol for the process evaluation of the Promoting Activity, Independence and Stability in Early Dementia (PrAISED), following changes required by the COVID-19 pandemic

Claudio Di Lorito, Alessandro Bosco, Sarah Goldberg, Roshan das Nair, Rebecca F. O’Brien et al. (14 authors)

BMJ Open2020-08-0113 citations

10.1136/bmjopen-2020-039305

A randomised controlled trial of an exercise intervention promoting activity, independence and stability in older adults with mild cognitive impairment and early dementia (PrAISED) - A Protocol.

Bajwa RK, Goldberg SE, Van der Wardt V, Burgon C, Di Lorito C, Godfrey M, Dunlop M, Logan P, Masud T, Gladman J, Smith H, Hood-Moore V, Booth V, Das Nair R, Pollock K, Vedhara K, Edwards RT, Jones C, Hoare Z, Brand A, Harwood RH.

2019-12-3027 citations

10.1186/s13063-019-3871-9

Interventions

The study will use a randomized controlled trial design to test the clinical and cost-effectiveness of a package of interventions designed to promote activity and independence and reduce falls, amongs

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age 65 years or over (no maximum) 2. Diagnosis of MCI or dementia (of any subtype, except Dementia with Lewy Bodies i.e. Parkinson's Disease Dementia) 3. Have a carer or friend who knows the participant well (at least one hour a week contact over the phone, internet, or in person), and is willing and able to act as an informant 4. Able to walk without human help 5. Able to communicate in English 6. Able to see, hear and have dexterity sufficiently to perform neuropsychological tests 7. Have capacity to give consent to participate, and consenting to do so

Exclusion criteria

Exclusion criteria: 1. Co-morbidity preventing participation (e.g. severe breathlessness, pain, psychosis, Parkinson’s or other severe neurological disease) 2. Life expectancy of less than one year 3. Likely to be unable to undertake the intervention regularly (e.g. planned elective surgery, planning to move away or commitments elsewhere).

Design outcomes

Primary

Measure	Time frame
Disability in activities of daily living, assessed using Disability Assessment in Dementia (DAD) at 12 months after randomisation	—

Secondary

Measure	Time frame
1. Self-reported Activities of Daily Living (ADL) measured using the Nottingham Extended ADL Scale at baseline and 12 month follow up 2. Falls rate measured by monthly diary up to 15 months 3. Quality of life measured by questionnaires DEMQOL-self, DEMQOL proxy and EQ5D3L (self) at baseline and 12 months; EQ5D5L (proxy) at baseline, 6 and 12 months; Demqol-u weights at 6 months 4. Cognition measured by three scales from CANTAB [Cambridge Cognition, 2015]; Montreal Cognitive Assessment, verbal fluency (from MoCA) at baseline and follow up 5. Time to first fall, rate of fractures and injurious falls measured by monthly diary and adverse events reporting (fractures). Data on falls, injurious falls and fractures are also collected at baseline 6. Rate of hospital and care home admissions, and days spent in hospital are measured by questionnaire at baseline, 6 and 12 months and by monthly diary and hospital administrative records at 12 months. Care home admissions also can be reported at any time in the study by staff 7. Rate of hospital and care home admissions, and days spent in hospital measured by monthly diary and hospital administrative records 8. Carer strain measured by Caregiver Strain Index at baseline and 12 month follow up 9. Carer health-related quality of life measured by questionnaire EQ5D-5L at baseline and 12 month follow up 10. Personality measured by Big Five Personality Inventory– short questionnaire at baseline and 12 month follow up	—

Measure

Time frame

1. Self-reported Activities of Daily Living (ADL) measured using the Nottingham Extended ADL Scale at baseline and 12 month follow up 2. Falls rate measured by monthly diary up to 15 months 3. Quality of life measured by questionnaires DEMQOL-self, DEMQOL proxy and EQ5D3L (self) at baseline and 12 months; EQ5D5L (proxy) at baseline, 6 and 12 months; Demqol-u weights at 6 months 4. Cognition measured by three scales from CANTAB [Cambridge Cognition, 2015]; Montreal Cognitive Assessment, verbal fluency (from MoCA) at baseline and follow up 5. Time to first fall, rate of fractures and injurious falls measured by monthly diary and adverse events reporting (fractures). Data on falls, injurious falls and fractures are also collected at baseline 6. Rate of hospital and care home admissions, and days spent in hospital are measured by questionnaire at baseline, 6 and 12 months and by monthly diary and hospital administrative records at 12 months. Care home admissions also can be reported at any time in the study by staff 7. Rate of hospital and care home admissions, and days spent in hospital measured by monthly diary and hospital administrative records 8. Carer strain measured by Caregiver Strain Index at baseline and 12 month follow up 9. Carer health-related quality of life measured by questionnaire EQ5D-5L at baseline and 12 month follow up 10. Personality measured by Big Five Personality Inventory– short questionnaire at baseline and 12 month follow up

—

Countries

England, United Kingdom

Outcome results

None listed