Hidden transmission routes and attitudes towards sleeping sickness in Nigeria

Contribution of maternal transmission and silent carriers in the epidemiology and persistence of African trypanosomiasis in human populations

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN15318880

Enrollment

400

Registered

2024-02-07

Start date

2023-11-01

Completion date

Unknown

Last updated

2024-02-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Attitudes and knowledge of Human African Trypanosomiasis (HAT), and the contribution of silent carriers and maternal transmission of HAT in Nigeria Infections and Infestations

Interventions

People who have previously had Human African Trypanosomiasis (HAT) will be recruited alongside their family members in their local towns and tested using in-field diagnostics for HAT, as well as blood

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Willing and able to provide written informed consent 2. Individuals aged 18 years and above and residing in the study area for the questionnaire aspect of the study 3. Individuals over the age of 1 years old and residing in the study area for the blood sampling aspect of the study 4. Previously tested positive or are related to primary case from prior study 5. Key Informants which will include Ministerial officials, local government policymakers, non-governmental organizations, WHO or FAO representatives in Nigeria, and key academic research contacts

Exclusion criteria

Exclusion criteria: 1. Unwillingness or unable to provide consent 2. Failure to establish relatedness primary case 3. Individuals aged less than 18 years for the questionnaire aspect of the study 4. Individuals less than 1 years old for the blood sampling aspect of the study

Design outcomes

Primary

Measure	Time frame
Individuals test positive or negative for HAT measured using the standard protocols for Card Agglutination Trypanosomiasis Test (CATT) within 24 hours of sample collection or by PCR within 1 year of sample collection	—

Secondary

Measure	Time frame
1. Number of asymptomatic carriers assessed by the number of positive individuals with no symptoms measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection 2. Maternal transmission cannot be assured but suspected if multiple family members test positive measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection 3. Attitudes and knowledge of HAT measured using a questionnaire and focus group on the same day as sample collection 4. Knowledge of the impact of COVID-19 on neglected tropical diseases in Nigeria ascertained by interview of policymakers at baseline	—

Measure

Time frame

1. Number of asymptomatic carriers assessed by the number of positive individuals with no symptoms measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection 2. Maternal transmission cannot be assured but suspected if multiple family members test positive measured using CATT within 24 hours of sample collection or PCR within 1 year of sample collection 3. Attitudes and knowledge of HAT measured using a questionnaire and focus group on the same day as sample collection 4. Knowledge of the impact of COVID-19 on neglected tropical diseases in Nigeria ascertained by interview of policymakers at baseline

—

Countries

Nigeria, United Kingdom

Contacts

Public ContactAyodele Majekodunmi

ayo.majekodunmi@ed.ac.uk+44 (0)131 650 8301

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026