Amelioration of the skin aging signs Skin and Connective Tissue Diseases Skin aging
Conditions
Interventions
Participants will be enrolled following a dermatological visit, then assigned to one of the two groups of the study in a 1:1 ratio according to a restricted randomization list generated by using an ap
Sponsors
Complife Italia Srl
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Healthy female subjects, showing mild to moderate signs of skin aging 2. Aged between 35 and 70 years old 3. Caucasian ethnicity 4. Observed an adequate wash-out period from similar studies 5. Give informed consent 6. Agree not to make any changes to their normal everyday routine 7. Agree not to use products with comparable activity to the study product 8. Agree not to expose in an intensive way to UV rays during the whole study duration 9. Available to take food supplements and comply with the study protocol 10. Agree to adopt an adequate contraceptive system
Exclusion criteria
Exclusion criteria: 1. Eating disorders (such as bulimia and anorexia) 2. Pregnant, breastfeeding or have planned a pregnancy during the study period 3. Previous history of gastrointestinal pathological conditions 5. Systemic pharmacological treatment 6. Under local pharmacological treatment on the skin area monitored during the test 7. Congenital or acquired immunodeficiency 8. Under treatment with food supplements which could interfere with the functionality of the product being study 9. Other skin alterations on the monitored area 10. Exposed in intensive way to UV rays during the 4 weeks prior to the study start 11. Considered as not suitable to participate in the study by the investigator 12. Reported food intolerance to one or more ingredients contained in the food supplement 13. Alcohol addiction 14. Drug addiction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Determination of the Skin moisturization evaluated as skin moisturization index using a Corneometer® and trans epidermal water loss using a TEWAMETER® probe at baseline and 4 weeks 2. Determination of skin elasticity and firmness, based on the suction/elongation method and the subsequent release of skin using Cutometer® at baseline and 4 weeks 3. Determination of skin profilometry measuring wrinkle depth and wrinkle volume using Primos 3D at baseline and 4 weeks 4. Acquisition of face digital pictures using a reflex digital camera at baseline, 1, 2, 3, and 4 weeks 5. Evaluation of serum hyaluronic acid level in a subgroup of participants at baseline, 1, 2, 3, and 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Products tolerability, efficacy, and acceptability evaluated using a self-assessment questionnaire at 4 weeks | — |
Countries
Italy
Outcome results
None listed