Assessing whether altering dietary sodium intake affects the aldosterone pattern of a healthy individual over 24 hours. Circulatory System
Conditions
Interventions
The intervention is modifying the salt content of the diet for 7 days with high and low salt diets (crossover). The low salt diet will contain 10 grams of salt per day. Wash-out will be a minimum of
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Age 18-40
Exclusion criteria
Exclusion criteria: 1. A history of hypertension, hyperaldosteronism, obstructive sleep apnoea, or heart disease 2. Taking medication that could affect aldosterone levels. This includes most antihypertensives and common inhalers 3. Anyone with a 1st degree family member who was diagnosed with hypertension below the age of 60 or has a diagnosis of primary hyperaldosteronism 4. Inability to understand spoken or written instructions given in English 5. Body mass index =30 kg/m2 6. Pregnancy 7. Alcohol consumption (>28 units/week), daily use of nicotine (including smoking and vaping) and daily use of recreational drugs due to risk of withdrawal symptoms during lab visits 8. Needle phobia 9. Allergy to any ingredient within the meal plans, or dietary requirements that cannot be catered for within the meal plans 10. Anyone who has worked shifts finishing after midnight in the past 4 weeks 11. Anyone with irregular sleep times (i.e. bedtime/wake time varies by more than +- 1 hour across a normal week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in aldosterone profiles measured using mass spectroscopy at the end of each dietary arm. A cosinor analysis will be undertaken of the 24-hour curves and dynamic markers, including: total area under the curve, magnitude of morning peak, number of peaks, or evening nadir. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Difference in the magnitude of the renin or aldosterone response to a change in posture measured using mass spectroscopy at the end of each dietary protocol (samples at 0, 20, 40, and 60 minutes standing) 2. Difference in magnitude of aldosterone response to exercise using microdialysis and serum tests at the end of 30 minutes on a static bike at 50-60% of VO2 peak 3. Difference in 24-hour urine aldosterone measured using mass spectrometry at the end of each dietary arm | — |
Countries
England, United Kingdom
Contacts
Public ContactTimothy Swinn
Outcome results
None listed