Women undergoing IVF Pregnancy and Childbirth
Conditions
Interventions
Comparison of the effectiveness between transdermal estradiol and oral estradiol on the endometrium of frozen embryo transfer (FET) at Hung Vuong Hospital between January 2020 to August 2021. Patients
Sponsors
Hung Vuong Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Women aged 18-45 2. No history of uterine intervention: suction or endoscopy 3. Has FET indication 4. Has at least one excellent/good frozen embryo before thawing 5. No pathological background: diabetes, high prolactin level, thyroid disorders, adrenal gland disorders. 6. Agree with FET indication 7. Volunteer to the study and has full contact information
Exclusion criteria
Exclusion criteria: 1. BMI > 30 2. Egg or embryo donor/receiver 3. Estradiol contraindication 4. Estradiol usage > 27 days 5. Not qualified for FET 6. Abnormal uterine, fallopian tube related to implantation 7. Endocrine disorders (kidney, liver or cardiac disease) 8. Patient does not agree to participate in the study 9. Patient does not adhere to the study 10. Does not follow drug prescription: 10.1. Patient forgot to consume drug for more than 2 consecutive or non-consecutive days 10.2. Patient stops using drug due to personal reasons 11. Late follow-up examination 12. Cannot read or write Vietnamese
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Thickness and shape of endometrium measured using vaginal ultrasound examination at baseline and on progesterone day 2. Serum estradiol concentration measured using immunoassay on progesterone day 3. Mean duration of treatment, recorded at time of procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Cycle cancellation rate of FET measured from medical records at the time of the patient who is indicated to cancel FET cycle such as insufficient endometrial thickness, loss of embryo viability during thawing, other 2. Implantation rate (number of gestational sacs containing a living embryo implanted in the uterus divided by the number of embryos transferred) measured from medical records 6 weeks after embryo transfer 3. Clinical pregnancy rate as measured by rising beta hCG levels starting at 14 days post embryo transfer, presence of gestational sac at 6-7 weeks post embryo transfer, and presence of fetal heartbeat at 6-7 weeks post embryo transfer | — |
Countries
Viet Nam
Contacts
Public ContactTuyet Hoang
Outcome results
None listed