Mineral trioxide aggregate (MTA) as an alternative root canal filling material

Evaluation of periapical healing following apical filling with mineral trioxide aggregate in mature teeth: a randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15285974

Enrollment

100

Registered

2015-06-23

Start date

2010-03-07

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patient requires root canal treatment for teeth with apical periodontitis. Oral Health Apical periodontitis

Interventions

Control group: conventional root canal filling with gutta-percha cones and root canal sealer. Treatment group: Mineral Trioxide Aggregate cement

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Included patients will be adult, healthy females who agreed to participate in the study and signed a consent form. The study will include mature teeth with radiographic periapical pathosis greater than 5mm in diameter.

Exclusion criteria

Exclusion criteria: The study sample will exclude teeth that are not restorable, teeth diagnosed with chronic periodontitis with advanced loss of periodontal support, third molars, and teeth with open apex.

Design outcomes

Primary

Measure	Time frame
Periapical healing assessed by conventional periapical radiographs. Measured 5 times, every 12 month post-operative for 5 years.	—

Secondary

Measure	Time frame
Periapical healing assessed by cone beam computed tomography. Measured twice, 1st and 5th year only.	—

Countries

Saudi Arabia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 1, 2026