A new method of estimating the volume of breast tissue removed following breast-conserving surgery using its weight and x-ray appearance

Development of a new approach to measure the volume of breast tissue removed during wide local excision using specimen weight and mammographic density

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN15283352

Enrollment

356

Registered

2023-06-14

Start date

2023-10-11

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with breast cancer undergoing breast-conserving surgery Cancer

Interventions

This is a proof-of-concept diagnostic study which evaluates a novel method of obtaining an estimate of the breast volume excised with a WLE by correlating specimen weight and radiological density adju

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women with a breast cancer diagnosis (both invasive and in-situ) undergoing breast-conserving surgery with or without oncoplastic techniques

Exclusion criteria

Exclusion criteria: Excision of skin and/or nipple-areola complex required

Design outcomes

Primary

Measure	Time frame
Comparison between surgical specimen volume estimate obtained with the new regression-based model and actual specimen volume obtained using the gold standard measurement (Archimedes/water displacement method) at the time of surgery measured with Bland-Altman analysis	—

Secondary

Measure	Time frame
Accuracy of the volume estimate obtained with the regression-based model in comparison with the current estimate method using paired t-tests and the Intraclass-Correlation-Coefficient at the time of surgery	—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 4, 2026