Acute febrile illness Infections and Infestations
Conditions
Interventions
Current interventions as of 05/06/2024:
This is a pragmatic, cluster-randomized controlled trial with two study arms each comprised of 15 clusters located in Battambang province, Cambodia. A cluster
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age =1 year 2. Unscheduled presentation for acute care 3. Documented fever (=37.5°C axillary) or hypothermia (<35.5°C) or history of fever in the last 24 hours
Exclusion criteria
Exclusion criteria: 1. Onset of illness =14 days 2. Presenting due to accident or trauma 3. Presenting =3 days after routine immunizations 4. Presenting within the follow-up period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients with acute fever aged =1 year who are prescribed antibiotics in the two study arms measured using data collected in the EDAM app by the end of the study | — |
Secondary
| Measure | Time frame |
|---|---|
| Current secondary outcome measures as of 04/10/2024: 1. The proportion of patients with full recovery at 7 and 14 days in intervention and control PHCs. 2. The proportion of patients referred to hospital at presentation in intervention and control PHCs. 3. The proportion of patients in intervention PHCs whose management followed the EDAM recommendations. 4. The proportion of patients with unplanned re-presentations to any healthcare facility at 7 and 14 days (if not fully recovered by 7 days) in intervention and control PHCs. 5. The proportion of patients prescribed antibiotics by a healthcare provider or who independently purchased antibiotics during the follow-up period, as determined by self-report, in intervention and control PHCs. 6. The proportion of patients with severe clinical outcomes (death or hospitalization) at 7 and 14 days (if not fully recovered by 7 days) in intervention and control PHCs, not including those referred to hospital at presentation. 7. The proportion of patients prescribed an antibiotic in intervention PHCs by CRP level (80 mg/L) 8. The usability and acceptability of EDAM for healthcare workers (a separate ethical approval application will be made for this work). 9. The cost-effectiveness of EDAM compared to routine care. _____ Previous secondary outcome measures: The following secondary outcome measures use data collected in the EDAM app, except where measures are defined: 1. Proportion of patients with full recovery at 7 and 14 days in the two study arms 2. Proportion of patients referred to hospital at presentation in the two study arms 3. Proportion of patients in the intervention arm whose management followed the EDAM recommendations 4. Proportion of patients with unplanned re-presentations at 7 and 14 days (if not fully recovered by 7 days) in the two study arms; for patients who re-present, proportion prescribed antibiotics 5. Proportion of patients with severe clinical outcomes (death or hospitalization) at 7 and 14 days ( | — |
Countries
Cambodia
Contacts
Public ContactRusheng Chew
Outcome results
None listed