Parkinson’s disease Nervous System Diseases
Conditions
Interventions
The intervention in this study comprises:
1. Brief withdrawal of the ongoing medications for PD
2. High-frequency electrical stimulation is applied unilaterally to the hemisphere contralateral to the
details in next section). After each block, the patient is asked to perform finger-tapping movements for 20 sec, by tapping their index fingers on their thumbs as wide and fast as possible. The order
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 18 years old and over with Parkinson's disease and deep brain stimulation electrodes implanted
Exclusion criteria
Exclusion criteria: 1. Cognitive impairment (judged by the clinician taking consent as not having the sufficient mental capacity to understand the study and its requirements). This is including anyone who, in the opinion of the clinician taking consent is unlikely to retain the sufficient mental capacity for the duration of their involvement in the study. 2. Severe motor impairment (judged by the clinician taking consent as not having the sufficient motor capacity to perform the motor task in the study) 3. Patients unwilling to briefly withdraw the ongoing medications 4. Severe visual impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Motor performance in reaching and finger-tapping movements assessed using the following methods during the study session: 1.1. Reaction time measured using the Tablet Drawing Monitor (Artist 22, XP-PEN, Japan) by quantifying the time from Go-cue until the pen moves out of the start point during the reaching movements 1.2. Velocity measured using the Tablet Drawing Monitor (Artist 22, XP-PEN, Japan) by dividing the accumulated distance by the time used during the reaching movements 1.3 Root-mean-square acceleration measured using a tri-axis accelerometer during the finger-tapping movements 2. Resting tremor severity measured using an accelerometer during the finger-tapping movements 3. Stimulation on time compared across different stimulation conditions during the reaching and finger-tapping tasks. The stimulation on/off time will be recorded automatically by the C++ program | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Modulations in subthalamic nucleus brain oscillations by movement and different stimulation protocols measured from the recorded bipolar LFP signals during the reaching movements during the study session 2. Association between changes in brain oscillations and belabour measured using linear mixed effect modelling during the reaching movements during the study session | — |
Countries
England, United Kingdom
Outcome results
None listed