Chronic obstructive pulmonary disease (COPD) Respiratory Other chronic obstructive pulmonary disease
Conditions
Interventions
1. An incremental exercise test on a cycle ergometer while breathing ambient air
2. Breathing air for 10 minutes and then equilibration with heliox (20% O2, 80% He), both at rest and w
Sponsors
University of Milan (Univrsità degli Studi di Milano) (Italy)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Stable COPD patients with stable airway obstruction with any level of forced expiratory volume in one second (FEV1) value expressed of predicted 2. Male or female patients, 40 years of age or older 3. Patients must be current or ex-smokers with a smoking history of more than 10 pack years 4. Patients must be to able to perform technical acceptable pulmonary function tests and must be able to perform an incremental exercise test on a cycle ergometer
Exclusion criteria
Exclusion criteria: 1. Patients with a signficant disease other than COPD that conditioning a risk for exercise testing (this is evaluated by medical investigators) 2. Patients with a history of asthma 3. Patients with a diagnosis of paroxysmal tachycardia, atrial fibrillation and recent history of myocardial infarction (less of 2 years) 4. Known active tubercolosis 5. History of cystic fibrosis 6. Pregnant women 7. Patients aged more than 85 years old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the ventilatory response to heliox administration in expiratory flow-limited and non flow-limited COPD patients both at rest and during normal, non-fatiguing physical activities. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Dyspnoea 2. Flow limitation 3. Forced expiratory volume in one second (FEV1) 4. Inspiratory capacity (IC) 5. Forced volume capacity (FVC) | — |
Countries
Italy
Outcome results
None listed