Small pinhole perforations created in the bone around the teeth to accelerate the rate of tooth movement during orthodontic alignment

Accelerating alignment of maxillary anterior crowding with micro-osteoperforations: a randomised clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN15080404

Enrollment

Registered

2019-12-04

Start date

2017-10-01

Completion date

Unknown

Last updated

2023-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthodontic treatment Oral Health Orthodontic treatment

Interventions

The domain of this study involves the localised minimally invasive surgical procedures known as MOPs in facilitating the first phase of fixed appliances treatment of alignment anterior maxillary arch

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age range 18-45 years old 2. Moderate crowding of maxillary arch (5-8mm) 3. Canine relationship between class III ¼ unit up to class II ½ unit 4. Extraction of upper first premolars with or without anchorage reinforcement 5. Healthy periodontal status with probing depth of lesser or equal to 3 mm, full-mouth plaque score lower or equal to 20 per cent, and full-mouth bleeding score lower or equal to 20 per cent (within 15 seconds after pocket depth probing) 6. All permanent maxillary teeth were present at least up to second molars 7. Undergoing conventional orthodontic treatment with McLaughlin, Bennett and Trevisi (MBT) brackets

Exclusion criteria

Exclusion criteria: 1. Previous orthodontic treatment either removable or fixed appliances 2. Patients with systemic diseases and compromised periodontal oral health 3. Taking medications which could interfere with tooth movement, such as anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers 4. Dental (e.g. hyperdontia, hypodontia) or craniofacial anomalies (e.g. Cleft lip and palate) 5. Smoker 6. Evidence of bone loss and root resorption on the dental panoramic tomography 7. History of dental trauma 8. Pregnant

Design outcomes

Primary

Measure	Time frame
Overall time taken for alignment of maxillary anterior crowding measured from patient records.	—

Secondary

Measure	Time frame
1. Alignment improvement percentage assessed monthly for six months: Little’s irregularity index (LII) was used to assess the overall changes and to measure the change of tooth alignment on the casts. Measurement of dental casts were calculated by using digital Vernier calliper 2. Degree of root resorption measured using long cone intra-oral periapical (IOPA) radiographs at baseline and six months 3. Pain perception measured using VAS monthly for six months	—

Measure

Time frame

1. Alignment improvement percentage assessed monthly for six months: Little’s irregularity index (LII) was used to assess the overall changes and to measure the change of tooth alignment on the casts. Measurement of dental casts were calculated by using digital Vernier calliper 2. Degree of root resorption measured using long cone intra-oral periapical (IOPA) radiographs at baseline and six months 3. Pain perception measured using VAS monthly for six months

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Countries

Malaysia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 21, 2026