Fibromyalgia Musculoskeletal Diseases Fibromyalgia
Conditions
Interventions
Twenty five patients with fibromyalgia syndrome, ten patients with unipolar major depression (MD) without pain, and thirty five healthy controls are recruited for the study. Patients undergo functiona
Sponsors
University of Würzburg
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years or over 2. Patients with: 2.1. Fibromyalgia syndrome 2.2. Unipolar major depression (MD) without pain 2.3.Healthy controls
Exclusion criteria
Exclusion criteria: 1. Other possible differential diagnoses (e.g. rheumatoid arthritis; post-surgery pain) 2. Current or prior cerebral disease (e.g. stroke, cerebral hemorrhage, head trauma) 3. Any clinically relevant psychiatric disorder (examined by systematic psychiatric interview)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscular pressure pain: fNIRS measurements were performed during the application of painful pressure on the muscle bulk of the finger extensors of the right side using a calibrated algesiometer. The stimulation conditions were as follows: pressure application for two seconds; pause for ten seconds between two stimuli; total of 40 stimuli, i.e. measurement at baseline and up to 8 minutes after first stimulation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Verbal fluency test (VFT): The VFT paradigm consisted of three conditions. Subjects were asked to produce as many different nouns as possible a) starting with a certain letter (A, F, and S), or b) belonging to the same category (animals, fruits, and flowers) or c) to name the days of the week as a control condition. Each condition lasted for 30 sec followed by 30 sec rest. Subjects worked on nine blocks in total (3 x letters, 3 x categories, 3 x week days), i.e. measurement at baseline and up to 9 minutes after start. | — |
Countries
Germany
Outcome results
None listed