Sexually transmitted infections in CHIEDZA (STICH): Impact of testing for Chlamydia trachomatis, Neisseria gonorrhoeae and Trichomonas vaginalis and comprehensive STI management among youth aged 16-24 years in Zimbabwe

Conditions

Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis Infections and Infestations

Dziva Chikwari C, Dauya E, Simms V, Kranzer K, Bandason T, Machiha A, Mugurungi O, Musiyandaka P, Mwaturura T, Tshuma N, Bernays S, Mavodza C, Tembo M, Martin K, Mackworth-Young CRS, Busza J, Francis SC, Hayes RJ, Ferrand RA.

2024-11-141 citations

10.1016/s2214-109x(24)00373-5

Risk factors for curable sexually transmitted infections among youth: findings from the STICH population survey in Zimbabwe

Kevin Martin, Ethel Dauya, Victoria Simms, Tsitsi Bandason, Steven Chifundo Azizi et al. (18 authors)

Sexually Transmitted Infections2024-06-132 citations

10.1136/sextrans-2024-056146

Evaluation of a community-based aetiological approach for sexually transmitted infections management for youth in Zimbabwe: intervention findings from the STICH cluster randomised trial.

Chikwari CD, Simms V, Kranzer K, Dauya E, Bandason T, Tembo M, Mavodza C, Machiha A, Mugurungi O, Musiyandaka P, Mwaturura T, Tshuma N, Bernays S, Mackworth-Young C, Busza J, Francis SC, Hayes RJ, Ferrand RA.

2023-08-039 citations

10.1016/j.eclinm.2023.102125

Interventions

The study will be conducted in two provinces of Zimbabwe (Harare and Bulawayo). A total of 16 study clusters, stratified by province, will be randomised in a 1:1 allocation ratio to one of the followi

Eligibility

Sex/Gender

All

Age

16 Years to 24 Years

Inclusion criteria

Inclusion criteria: STICH intervention: 1. Lives within one of the STICH intervention clusters 2. Aged 16-24 years 3. Attends CHIEDZA service between 21 September 2020 and 30 September 2021 (Harare) or 1 January 2021 and 31 December 2021 (Bulawayo), the times when the STICH intervention is operational Prevalence survey: 1. Aged 18-24 years 2. Consent from the household to participate 3. Surveyed on a day allocated to STICH sampling

Exclusion criteria

Exclusion criteria: STICH intervention: 1. Has had an STI test within the previous 3 months Prevalence survey: 1. Unable or willing to provide informed consent 2. Unable or unwilling to provide a urine sample

Design outcomes

Primary

Measure	Time frame
The proportion of participants reporting a positive test result for any of Chlamydia trachomatis, Neisseria gonorrhea, and/or Trichomonas vaginalis measured using a community cross-sectional survey where urine samples for STI testing will be collected at a single time point for each participant. Indeterminate test results will be excluded.	—

Secondary

Measure	Time frame
1. The proportion of participants with each of the following STIs: 1.1. Chlamydia trachomatis measured using urine samples for STI testing collected at a single time point for each participant 1.2. Neisseria gonorrhea measured using urine samples for STI testing collected at a single time point for each participant 1.3. Trichomonas vaginalis measured using testing urine samples for STI testing collected at a single time point for each participant 2. The impact of STI testing and treatment of young people on population-level prevalence of Chlamydia trachomatis, Neisseria gonorrhea, and Trichomonas vaginalis measured by counting the numbers of participants who attend, who are tested, and who take up treatment, recorded on service uptake forms for the intervention, at a single time point for each participant 3. Uptake, prevalence, and yield of STI testing and treatment measured by counting the numbers of participants who attend, who are tested, and who take up treatment, recorded on service uptake forms for the intervention, at a single time point for each participant 4. Uptake of partner notification measured by counting the number of participants who take up partner notification, recorded on service uptake forms for the intervention, at a single time point for each participant 5. Acceptability of self-collected vaginal swabs measured using structured questionnaires administered by research assistants to the study participants during the survey as well as service uptake data in the intervention collected at a single time point for each participant 6. Factors predicting acceptance of STI testing measured using structured questionnaires administered by research assistants to the study participants during the survey as well as service uptake data in the intervention collected at a single time point for each participant 7. Knowledge, attitudes, and practices towards STIs, STI testing, and partner notification measured using structured questionnaires administered by resear	—

Measure

Time frame

1. The proportion of participants with each of the following STIs: 1.1. Chlamydia trachomatis measured using urine samples for STI testing collected at a single time point for each participant 1.2. Neisseria gonorrhea measured using urine samples for STI testing collected at a single time point for each participant 1.3. Trichomonas vaginalis measured using testing urine samples for STI testing collected at a single time point for each participant 2. The impact of STI testing and treatment of young people on population-level prevalence of Chlamydia trachomatis, Neisseria gonorrhea, and Trichomonas vaginalis measured by counting the numbers of participants who attend, who are tested, and who take up treatment, recorded on service uptake forms for the intervention, at a single time point for each participant 3. Uptake, prevalence, and yield of STI testing and treatment measured by counting the numbers of participants who attend, who are tested, and who take up treatment, recorded on service uptake forms for the intervention, at a single time point for each participant 4. Uptake of partner notification measured by counting the number of participants who take up partner notification, recorded on service uptake forms for the intervention, at a single time point for each participant 5. Acceptability of self-collected vaginal swabs measured using structured questionnaires administered by research assistants to the study participants during the survey as well as service uptake data in the intervention collected at a single time point for each participant 6. Factors predicting acceptance of STI testing measured using structured questionnaires administered by research assistants to the study participants during the survey as well as service uptake data in the intervention collected at a single time point for each participant 7. Knowledge, attitudes, and practices towards STIs, STI testing, and partner notification measured using structured questionnaires administered by resear

—

Countries

Zimbabwe

Outcome results

None listed