Pelvic organ prolapse has a mixed etiology – hereditary and acquired. Collagen is playing a major role in pelvic floor supportive structures. The role of single nucleotide polymorphism of the collagen genes remain controversial. This inconsistency has resulted in the current study in which several polymorphisms in collagen in saliva samples of women will be investigated. Urological and Genital Diseases
Conditions
Interventions
This is cross sectional case-control study evaluating the prevalence of single nucleotide polymorphism (SNP) in collagen type 3 alpha 1 chain (COL3A1), collagen type 1 alpha 1 chain (COL1A1) and coll
Sponsors
Ministry of Health of Russian Federation
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Adult women suffering from pelvic organ prolapse and healthy women as controls 2. Aged 18 and older
Exclusion criteria
Exclusion criteria: Hereditary diseases with a known increased risk of POP, such as Marfan or Ehlers-Danlos syndrome and previous surgeries for POP for the control group
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Single nucleotide polymorphisms in COL3A1 is investigated using Sanger gene sequencing method. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Single nucleotide polymorphisms in COL1A1 gene is measured using Sanger gene sequencing method 2. Single nucleotide polymorphisms in COL 18A gene is measured using Sanger gene sequencing method | — |
Countries
Russian Federation
Outcome results
None listed