Cardiac surgery Surgery Cardiac surgery
Conditions
Interventions
After cardiac surgery, participants are randomised to one of two treatment groups using coin randomisation.
1. The treatment group receive an intravenous infusion of 75 mg diclofenac (
Sponsors
University Medical Centre Maribor
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adult aged 20 - 85 years 2. Operated for elective cardiac surgery using extracorporeal circuit
Exclusion criteria
Exclusion criteria: 1. History of peptic ulcer disease, gastointestinal bleeding 2. Renal and liver insufficiency 3. Allergy for nonsteroidal analgetics 4. Increased bleeding during surgery 5. Increased bleeding after surgery, as defined by the chest tube drainage of more than 300 ml per hour during the first 3 hours after surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain is measured using the NRS (numerical rating scale) for pain assessment at 1 hour intervals until 20 hours after surgery 2. The use of piritramide is recorded within the first 20 hours after surgery 3. The use of blood and blood product is recorded within the first 20 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heamodynamic data (invasive blood pressure and heart rate) is measured using Phillips MX 800 monitor at 1 hour intervals until 20 hours after surgery 2. Sternal drain blood loss is measured using Sternal drainage system Atrium at 1 hour intervals until 20 hours after surgery 3. Time to extubation and time of ICU stay is recorded. 4. Unfavourable side effects are recorded during the ICU stay | — |
Countries
Slovenia
Outcome results
None listed