Dysphagia following radiotherapy or chemotherapy for head and neck cancer Signs and Symptoms
Conditions
Interventions
In the first phase of this study, patients will be asked to complete self-assessment using the Sydney Swallow Questionnaire and return it with their signed consent form. This will allow researchers to
the M. D. Anderson Dysphagia Inventory (MDADI), and a repeat of the self assessment Swallowing Questionnaire. 10 ml of blood and 5 ml of saliva will be collected by a clinic nurse, doctor or qualified
Sponsors
Queen Mary University of London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 18 years and over (no upper limit) 2. Treated for primary head and neck cancer with radiotherapy or radio-chemotherapy 3. Between 1 and 6 years post-treatment at the time of recruitment
Exclusion criteria
Exclusion criteria: 1. Not deemed able to give informed consent 2. Thyroid cancer 3. Head and neck surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The association between genetic variants and severe radiotoxicity in head and neck cancer patients, with the association between common SNPs and radiation-induced dysphagia (which determines case/control status) assessed using the PLINK suite of genetic analysis programs from Harvard University. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Prevalence and degree of dysphagia as determined by scores on the Sydney Swallowing Scale at the two visits 2. The proportion of saliva samples that are suitable for GWAS analysis | — |
Countries
England, United Kingdom
Contacts
Public ContactAndrew Lyons
Outcome results
None listed