Dental caries Oral Health Dental caries
Conditions
Interventions
Randomisation was carried out based on a randomisation list generated by the biostatistician. 24 nasopharyngeal carcinoma patients treated with radiotherapy were randomly assigned to the control group
Sponsors
National Dental Centre Singapore
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged 21 years or older 2. Ability to understand and provide informed consent prior to starting the study 3. Patient has no advanced periodontal disease 4. Patient has at least eight remaining teeth at start of the study
Exclusion criteria
Exclusion criteria: 1. Patient who has previously undergone head and neck radiotherapy 2. Uncontrolled systemic disease (eg hypertension, diabetes) 3. Patient on palliative care 4. Pregnancy (self declared) 5. Patient with milk allergy (self declared) 6. Patient with hydroxybenzoates (preservative) allergy (self declared)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Caries lesion progression assessed using the International Caries Detection and Assessment System (ICDAS) visual criteria at baseline, 2 weeks and 3 months after completion of radiotherapy | — |
Secondary
| Measure | Time frame |
|---|---|
| Fluoride ion concentration in resting saliva measured using a fluoride-specific electrode at baseline, one week before start of radiotherapy, mid-radiotherapy, 2 weeks and 3 months after end of radiotherapy | — |
Countries
Singapore
Contacts
Public ContactEdwin Liu
Outcome results
None listed