Investigating whether advanced MR imaging can be used to demonstrate trapped nerves in healthy volunteers

Assessing cervical foraminal stenosis: volumetric MRI study in healthy volunteers

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14904663

Enrollment

Registered

2020-10-15

Start date

2021-03-01

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Evaluation of cervical foraminal stenosis in healthy volunteers Musculoskeletal Diseases

Interventions

Three-dimensional volumetric data of the cervical spine will be obtained from an MRI scan. The anatomy of the cervical nerve root canal will be analysed to measure areas of nerve root compression usin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age over 40 years 2. Able to provide fully informed written consent 3. Able to lie flat for 1 hour in an MRI scanner 4. Females of childbearing age must be using effective contraception 5. Sufficient understanding of English to participate in the trial

Exclusion criteria

Exclusion criteria: 1. Cervical myelopathy 2. History of cervical trauma 3. Evidence of suspected or histologically proven tumour 4. Previous cervical spine surgery 5. Non-MRI compatible implantable device e.g. pacemaker 6. Unable to have MRI scan due to claustrophobia 7. Female participants must not be pregnant and if of childbearing age must be using adequate contraception

Design outcomes

Primary

Measure	Time frame
The inter-rater reliability for the Kim grading system on measuring the narrowest diameter of the nerve root canal. This will be applied to the standard axial images and modified plain images. Success will be determined if there is a significant improvement in the inter-observer reliability. The MRI scan will be graded once to gain the initial reading (which will then be used for inter-rater correlation) and then the same rater will grade the same scan again to determine intra-rater correlation.	—

Measure

Time frame

The inter-rater reliability for the Kim grading system on measuring the narrowest diameter of the nerve root canal. This will be applied to the standard axial images and modified plain images. Success will be determined if there is a significant improvement in the inter-observer reliability. The MRI scan will be graded once to gain the initial reading (which will then be used for inter-rater correlation) and then the same rater will grade the same scan again to determine intra-rater correlation.

—

Secondary

Measure	Time frame
1. The inter-rater reliability for subjective score, Kim grade, Modified Kim Grade, Park Grade, length and laterality of compression 2. The intra-rater reliability for narrowest diameter, subjective score, Kim grade, Modified Kim Grade, Park Grade, length and laterality of compression The MRI scan will be graded once to gain the initial reading (which will then be used for inter-rater correlation) and then the same rater will grade the same scan again to determine intra-rater correlation.	—

Measure

Time frame

1. The inter-rater reliability for subjective score, Kim grade, Modified Kim Grade, Park Grade, length and laterality of compression 2. The intra-rater reliability for narrowest diameter, subjective score, Kim grade, Modified Kim Grade, Park Grade, length and laterality of compression The MRI scan will be graded once to gain the initial reading (which will then be used for inter-rater correlation) and then the same rater will grade the same scan again to determine intra-rater correlation.

—

Countries

England, United Kingdom

Contacts

Public ContactSimon Thomson

simon.thomson1@nhs.net+44 (0)1133928567

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026