Reduction of blood pressure Circulatory System
Conditions
Interventions
The study is conducted using a counterbalanced crossover trial method, with each participant acting as their own control. Participants will be randomised to intervention order in a counterbalanced met
Sponsors
University of Leeds
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 18-56 2. BMI more than 27kg/m2 but less than35kg/m2 3. Male and female, local to the Leeds area 4. Presence of high blood pressure 5. Sufficient knowledge and understanding of the English language (preferably first language)
Exclusion criteria
Exclusion criteria: 1. For women – pregnancy, lactation, perimenopause/menopause 2. Food allergy or intolerance to any of the study foods 3. Medical conditions – clinical depression, thyroid diseases, hypertension, type 1 or type 2 diabetes, or blood diseases 4. Using any medication for hypertension or cholesterol-lowering sterols 5. Recent blood donation (<3 months) 6. Participation in simultaneous studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure measured using an automatic blood pressure cuff (Omron) at baseline, and every 20 minutes after consumption of the drink and test meal for a 2 ½ hour postprandial period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Interstitial glucose measured using a Continuous Glucose Monitor (Freestyle Libre, Abbott) every 15 minutes. 2. Cognitive function (verbal memory, executive function, pattern separation) measured using a Visual Verbal learning test, Tower of Hanoi and Pattern separation at baseline and then 90 minutes after the consumption of the drink | — |
Countries
England, United Kingdom
Contacts
Public ContactLucy Ellis
Outcome results
None listed