Healthy volunteers Digestive System
Conditions
Interventions
Current interventions as of 04/10/2019:
The study will be a randomized, cross-over dietary intervention on 25 participants. Each subject will require coming for 4 visits control, and 3
Sponsors
King Abdulaziz University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years 2. Healthy 3. BMI 18 - 30
Exclusion criteria
Exclusion criteria: 1. Regular drug therapy 2. Diabetes (fasting glucose >126 mg/dL, or anti-diabetic treatment) 3. Hypothydroidism or thyroxine treatment 4. Ill or suffer from any underlying health condition that can affect their ability to taste, smell, chew, digest or excrete of food 5. History of cancer or cancer treatment 6. Active or recently diagnosed intestinal malabsorption or disorders associated with malabsorption: Crohn’s disease, short bowel syndrome, Pancreatic insufficiency, cystic fibrosis, Tropical Sprue, whipple’s disease, chronic pancreatitis, gastrojejunostomy, surgical treatments for obesity, cholestasis, biliary atresia, parasite infections, HIV/AIDS 7. Use of medication known to cause malabsorption: tetracycline, cholestyramine, thiazide diuretics, aluminium/magnesium hydroxide, colchicine, neomycin, methotrexate, methyldopa, and allopurinol, and laxatives 8. Illegal drug use or chronic alcoholism 9. History of allergy or intolerance to any components used in the study 10. Women who are pregnant, lactating or actively trying to conceive 11. Participation in other clinical trials that may impact on outcome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measure as of 04/10/2019: Post-prandial glucose peak measured by continuous glucose monitoring system at 30, 60, 90, 120, 150 and 180min after eating Previous primary outcome measure: Blood glucose will be measured on arrival the following morning by taking blood via a finger prick test then small device for continuous glucose monitoring will be attached to their upper arm by qualified practitioner. Two more blood sample will be taken at 90 min and 180 min after eating | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Insulin and satiety hormones measured using the same blood samples collected as above. 2. Inflammatory markers measured using the same blood samples collected as above. 3. Food habits measured by the food frequency questionnaire during each visit. | — |
Countries
England, United Kingdom
Outcome results
None listed