Sustaining the control of intestinal schistosomiasis mansoni in Western Kenya

Comparison of school-based mass drug administration delivery strategies for control of Schistosoma mansoni infections in Western Kenya

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14849830

Enrollment

40000

Registered

2015-11-18

Start date

2010-12-01

Completion date

Unknown

Last updated

2017-11-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schistosomiasis Infections and Infestations

Interventions

In a first step, in-depth parasitological surveys are carried out in 75 schools where the prevalence of S. mansoni (i.e. number of infections) amongst schoolchildren ranges between 10% and 24%. Preval

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Schoolchildren, either male or female, aged 9-12 years, attending the selected schools (in each study year) 2. First-year students, either male or female, attending the selected schools (in years 1 and 5) 3. Written informed consent signed by parents or legal guardians of the schoolchildren 4. Oral assent from schoolchildren 5. At least one stool sample provided over three consecutive days from 9- to 12- years- old children each study year 6. At least one stool sample provided from first-year students in years 1 and 5

Exclusion criteria

Exclusion criteria: 1. Children not aged 9-12 years (in years 2, 3 and 4) 2. Children not aged 9-12 years or being first-year students (in years 1 and 5) 3. No written informed consent by parents or legal guardians of schoolchildren 4. No oral assent given by schoolchildren 5. No stool sample provided (for 9- to 12-year-old children in each study year; for first-year students in years 1 and 5)

Design outcomes

Primary

Measure	Time frame
Identification of the most cost-effective strategy that is able to reduce S. mansoni infection from moderate (10-24%) to low prevalence levels (<10%). Measured by change in prevalence and intensity of Schistosoma mansoni infection in cohorts of 9- to 12-year-old children over the four years of intervention.	—

Secondary

Measure	Time frame
1. Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren, using Kato-Katz thick smears 2. Prevalence and intensity of S. mansoni infections in first-year schoolchildren, using Kato-Katz thick smears 3. Control of morbidity due to S. mansoni (reduction of the prevalence to <10%) in the 75 schools 4. Identification of S. mansoni risk factors 5. Mapping and prediction of the distribution S. mansoni in Western Kenya Measured by changes in force of transmission, as assessed by infection prevalence and intensity of S. mansoni in first-year students and adults.	—

Measure

Time frame

1. Prevalence and intensity of S. mansoni infections in 9- to-12- year-old schoolchildren, using Kato-Katz thick smears 2. Prevalence and intensity of S. mansoni infections in first-year schoolchildren, using Kato-Katz thick smears 3. Control of morbidity due to S. mansoni (reduction of the prevalence to <10%) in the 75 schools 4. Identification of S. mansoni risk factors 5. Mapping and prediction of the distribution S. mansoni in Western Kenya Measured by changes in force of transmission, as assessed by infection prevalence and intensity of S. mansoni in first-year students and adults.

—

Countries

Kenya

Contacts

Public ContactDiana Karanja

diana@cohesu.com254-72-215-4838

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 13, 2026