Obesity and chronic periodontitis Oral Health Chronic periodontitis
Conditions
Interventions
Both groups (BMI obese and BMI normal) received standard non-surgical periodontal therapy consisting of oral hygiene instructions and full mouth debridement within 24 hours, with 6 months follow-up.
Sponsors
Joint UCLH/UCL Biomedical Research Unit
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Individuals at least 35 years of age and in good general health 2. Have BMI between 20-24.9 (WHO Normal) or BMI =30 (WHO Obese) 3. Participants must have a minimum of 15 natural teeth 4. Participants must have severe periodontal disease defined as >30% sites with PPD =5 attachment loss (1998 AAP classification) 5. Participants must voluntarily agree to sign the consent form
Exclusion criteria
Exclusion criteria: 1. BMI between 25-29.9 (WHO overweight) 2. Current smokers or former smokers who have smoked within the previous 5 years 3. History of diabetes 4. Uncontrolled or currently undergoing treatment for serious systemic medical conditions including hepatic disease, renal disease, transmittable diseases, cancer, or HIV 5. On chronic treatment (defined as 2 weeks or more) of antibiotic, anti-inflammatory or anticoagulant therapy during the month preceding the baseline exam 6. History of alcohol or drug abuse 7. Self reported pregnancy or lactation (this criterion is due to oral tissue changes related to pregnancy and nursing which can affect interpretation of study results) 8. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the subject inappropriate for entry into this study 9. Participation in any other dental study concurrently
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Periodontal probing pocket depth at 2 and 6 months following completion of non-surgical intensive periodontal therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage of periodontal pockets >4 mm at 2 and 6 months 2. Full mouth bleeding on probing percentage at 2 and 6 months | — |
Countries
England, United Kingdom
Outcome results
None listed