Exercise training among children with cerebral palsy to increase health and well-being Nervous System Diseases
Conditions
Interventions
Two different exercise regimes on spinning-bikes, Moderate Intensity Continuous Training (MICT) and High Intensity Interval Training (HIIT), will be performed three times per week for 16-weeks with 16
lifestyle changes as well as interventions must be implemented through the family. Feasibility testing aims to analyze clinical, procedural, and methodological uncertainties of the exercise testing an
Sponsors
Lund University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Ambulant children with CP defined as GMFCS-E&R I-II 2. Healthy controls: ambulant children who are TD and not participating in any regular and planned leisure time physical exercise will be included in the study.
Exclusion criteria
Exclusion criteria: 1. Ambulant children with CP walking with a walking aid (GMFCS-E&R III) 2. Ambulant children who are TD with other neurological diagnoses, metabolic diagnoses, orthopaedic disabilities, asthma, heart diseases, cognitive impairment, or indigestion of regular medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of completed exercise sessions measured using patient records at end of study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of completed tests measured using patient records at end of study 2. Exercise test VO2, VCO2, VE, RER, BF, VO2/kg adn HR before and after exercise period. 3. Body composition by bio impedance before and after exercise period. 4. Range of motion according to CPUP before and after exercise period. 5. Spaticity according to CPUP before and after exercise period. 6. Variance i watt during each exercise session. 7. Variance in HR during each exercise session. 8. Physical activity assessed by accelerometry before and after exercise period. 9. Quality of life (EQ5D) before and after exercise period. 10. Bowl function assessed by the Bristol scale before and after exercise period. 11. Changes in blood biomarkers BDNF, VEGF, ACTH, GH, CRP, IL-6, IGF-1, IGFBP-3, TNF-a and insulin, assessed in plasma collected from venues blood sampling before and after each exercise test performed before and after the exercise period 12. Capillary blood glucose and lactate collected before and after each exercise test performed before and after the exercise period. 13. Semi-structed interviews about the experiences of participating in the testing and exercise sessions | — |
Countries
Sweden
Contacts
Public ContactÅsa Tornberg
Outcome results
None listed