Sepsis, severe sepsis and septic shock Infections and Infestations Sepsis
Conditions
Interventions
This study is observational and uses CEUS to dynamically detect the changes in renal microcirculation perfusion in the AKI and non-AKI groups. If the problem about renal microcirculation perfusion was
Sponsors
Zhejiang Provincial Natural Science Foundation of China
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with sepsis, severe sepsis and septic shock can be admitted for the enrollment if they were over 18 years old 2. Sepsis is defined as an acute change in total SOFA score = 2 points as a result of anti-inflammatory function. The definition of septic shock is sepsis with persistent hypotension, requiring vasopressors for the maintenance of mean arterial pressure (MAP) =65 mmHg and with serum lactate level > 2 mmol/L (18mg/dL), inspite of the administration of adequate volume.
Exclusion criteria
Exclusion criteria: 1. EICU stay less than 24 hours or refuse related salvage treatment 2. Patients with chronic kidney disease and long-term hemodialysis 3. Critically ill patient who had already started RRT due to AKI before EICU admission 4. Past history of kidney transplantation 5. AKI caused by obstructive causes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Contrast-enhanced ultrasound examination results will be measured using the the time-intensity curve (TIC) at day 0, 1, 3 and 7 following EICU entry. | — |
Secondary
| Measure | Time frame |
|---|---|
| The flow sheet of intensive care unit, routine hematology and biochemistry profile will be measured manually every day.The patient's survival status will be measured using hospital outpatient visits or telephone interviews at 1 months, 3 months after discharge. | — |
Countries
China
Contacts
Public ContactZhongheng Zhang
Outcome results
None listed