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PHOENIX-Feasibility: picking up hidden osteoporosis effectively during normal CT imaging without additional x-rays

PHOENIX-f: a feasibility study for early identification of vertebral fractures and osteoporosis by opportunistically using CT scans undertaken for other purposes

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN14722819
Enrollment
625
Registered
2019-08-15
Start date
2019-10-29
Completion date
Unknown
Last updated
2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis Musculoskeletal Diseases

Interventions

Current intervention: The intervention is a FRAX questionnaire and a review of CT scans repurposed to look for vertebral fractures and early osteoporosis using software developed for the diagnosis of

Sponsors

Cambridge University NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Attend one of five participating radiology departments 2. Volunteers able to provide informed consent 3. Women aged =65 - 90 and men aged =75 – 90 years inclusive 4. Attending for CT, for any clinical reason, where the spine and/or hips are visible in the scan images

Exclusion criteria

Exclusion criteria: 1. Aged > 90 2. Bilateral metalwork in hips 3. Unable to provide valid consent 4. Known to be receiving prescription treatment for osteoporosis other than calcium/vitamin D (i.e. bisphosphonate drug, strontium ranelate, denosumab, raloxifene or teriparatide) 5. Prone CT scan

Design outcomes

Primary

MeasureTime frame
1. Recruitment rate recorded as the number of eligible participants who consent to participate in the study in 10 months 2. Attrition rate recorded as the number of participants who consent to participate that remain in the study until the end of follow up one year after recruitment

Secondary

MeasureTime frame
There are no secondary outcome measures

Countries

England, United Kingdom

Contacts

Public ContactKaren Willoughby
kw369@medschl.cam.ac.uk+44 (0)1223 217580

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 12, 2026