Effect of nutritional supplements in moderate underweight children

Effect of nutritional supplements on energy intake, appetite, lipid profile and micronutrient status of moderate underweight children

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14718521

Enrollment

Registered

2018-01-16

Start date

2017-12-20

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Moderate Malnutrition Nutritional, Metabolic, Endocrine Moderate Malnutrition

Interventions

The participants are randomly allocated to either receiving Ready to Use Supplementary Food (RUSF) (Acha Mum, provided by WFP) or to the Placebo group. After taking consents from part

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 5-10 years old 2. Underweight; moderate with -2 and -3 BMI Z score

Exclusion criteria

Exclusion criteria: 1. Eating disorder 2. Allergic to supplements or any food allergy 3. Gastro-intestinal tract surgery 4. Gastrointestinal tract disorders 5. Previously taking any supplement regularly 6. Previously taking such medications that interacts with appetite

Design outcomes

Primary

Measure	Time frame
1. Weight is measured using a calibrated electronic scale at baseline and four weeks 2. Height is measured using with a portable stadiometer (Seca, Leicester, UK) using a stretch stature method at baseline and four weeks 3. Mid upper arm circumference is measured using the Shakir measuring tape on the “non dominant hand” at baseline and four weeks 4. Skin fold measurement is measured using a Holtain skin fold calliper (Holtain LTD, Crosswell, UK) to the nearest 0.2 mm at baseline and four weeks 5. Appetite is measured using a validated appetite questionnaire at baseline and four weeks 6. Head circumference is measured using the Lasso-o measuring tape at baseline and four weeks 7. Waist to hip ratio is measured using Lasso-o measuring tape at baseline and four weeks 8. Energy intake will be measured using Windiet® software 9. Lipid profile will be analyzed using Cobas C3 analyzer 10. Hemoglobin (Hb) levels are checked by using hematology analyzer 11. Status of Iron (Fe), zinc (Zn) and copper (Cu) in plasma are analyzed by atomic absorption spectrometry (AAS) 12. Vitamin D and Calcium (Ca) levels are checked using a Cobas 8000 Modular Analyzer.	—

Measure

Time frame

1. Weight is measured using a calibrated electronic scale at baseline and four weeks 2. Height is measured using with a portable stadiometer (Seca, Leicester, UK) using a stretch stature method at baseline and four weeks 3. Mid upper arm circumference is measured using the Shakir measuring tape on the “non dominant hand” at baseline and four weeks 4. Skin fold measurement is measured using a Holtain skin fold calliper (Holtain LTD, Crosswell, UK) to the nearest 0.2 mm at baseline and four weeks 5. Appetite is measured using a validated appetite questionnaire at baseline and four weeks 6. Head circumference is measured using the Lasso-o measuring tape at baseline and four weeks 7. Waist to hip ratio is measured using Lasso-o measuring tape at baseline and four weeks 8. Energy intake will be measured using Windiet® software 9. Lipid profile will be analyzed using Cobas C3 analyzer 10. Hemoglobin (Hb) levels are checked by using hematology analyzer 11. Status of Iron (Fe), zinc (Zn) and copper (Cu) in plasma are analyzed by atomic absorption spectrometry (AAS) 12. Vitamin D and Calcium (Ca) levels are checked using a Cobas 8000 Modular Analyzer.

—

Secondary

Measure	Time frame
1. Taste acceptability of supplements is measured using validated sensory evaluation questionnaires at baseline and four weeks 2. Perceived benefits of the supplements by parents/carers are measured using validated parent perception questionnaires at baseline and four weeks 3. Perceived side effects of the supplements by parents/carers measured using validated parent perception questionnaires at baseline and four weeks 4. Socio-economic status of participant will be categorized using validated demographic questionnaire	—

Measure

Time frame

1. Taste acceptability of supplements is measured using validated sensory evaluation questionnaires at baseline and four weeks 2. Perceived benefits of the supplements by parents/carers are measured using validated parent perception questionnaires at baseline and four weeks 3. Perceived side effects of the supplements by parents/carers measured using validated parent perception questionnaires at baseline and four weeks 4. Socio-economic status of participant will be categorized using validated demographic questionnaire

—

Countries

Pakistan

Contacts

Public ContactAqsa Zubair

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026