Prevention of vasovagal syncope in patients with orthostatic intolerance Not Applicable
Conditions
Interventions
Participants were randomised, in single-blind crossover fashion, to either a 500 ml drink of room temperature water, which was the control condition (20°C) (ROOM), a 500 ml drink of ice-cold water (0-
Sponsors
Simon Fraser University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy volunteers 19-50 years of age
Exclusion criteria
Exclusion criteria: 1. 50 years old 2. Pregnant 3. Trying to conceive 4. Prior history of cardiovascular or neurological disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Orthostatic tolerance measured by time to presyncope following the head-up tilt test and subsequent progressive lower body negative pressure. Each intervention was applied on a different day, with a single day testing and endpoint (3 x one day). | — |
Secondary
| Measure | Time frame |
|---|---|
| Each intervention was applied on a different day, with a single day testing and endpoint (3 x one day): 1. Cardiovascular stability measured by Finometer, echocardiography and forearm ultrasound Doppler following the head-up tilt test and subsequent progressive lower body negative pressure 2. Cerebrovascular stability measured by middle cerebral artery ultrasound Doppler following the head-up tilt test and subsequent progressive lower body negative pressure | — |
Countries
Canada
Contacts
Public ContactVictoria Claydon
Outcome results
None listed