Breast cancer Cancer Breast
Conditions
Interventions
1. Regimen A: tamoxifen 20 mg daily for 4 years
2. Regimen B: tamoxifen 20 mg daily for 4 years plus chemotherapy, single agent epirubicin repeated every 4 weeks for six cycles
Sponsors
Pharmacia Ltd & Upjohn (UK)
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Post-menopausal as determined by: 1.1. Last menstrual cycle 12 months before surgery 1.2. Patients any age with previous bilateral oophorectomy 1.3. Patients aged greater than 50 years who have had hysterectomy without oopherectomy as long as the reason for surgery was not a malignancy 2. Aged less than 75 years 3. Histologically proven non metastatic T1-T3 with at least one involved ipsilateral axillary node 4. Adequate renal and haematological function 5. No prior history of malignant breast tumours 6. No bilateral malignancy or inflammatory breast cancer 7. No previous or concomitant malignancy, except squamous or basal cell carcinoma of the skin which has been effectively treated or carcinoma of the cervix in situ which has been treated operatively only 8. No non malignant systemic disease 9. No definite indication for chemotherapy
Exclusion criteria
Exclusion criteria: Not provided at time of registration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Belgium, France, Greece, Netherlands, Spain, United Kingdom
Outcome results
None listed