Can the results of non-surgical therapy of periodontitis be improved by the use of enamel matrix proteins?

Flapless application of enamel matrix derivative in periodontal retreatment: a multicenter feasibility randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14654696

Enrollment

Registered

2020-07-29

Start date

2015-10-01

Completion date

Unknown

Last updated

2020-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalised periodontitis Oral Health Periodontal disease, unspecified

Interventions

Adult patients presenting at re-evaluation after initial non-surgical periodontal therapy for generalised periodontitis with at least 2 teeth with residual probing pocket depths (PPD) = 5 and = 8 mm,

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult patients 2. Two residual pockets with probing depth = 5 mm and = 8 mm, bleeding and probing (BOP), mobility = degree 1 and without furcation involvement

Exclusion criteria

Exclusion criteria: 1. Full mouth plaque score (modified O'Leary et al. 1972) > 20% 2. Uncontrolled systemic disease, requiring high dose steroid therapy, radiation or other immune-suppressive therapy and history of malignant disease in the oral cavity or previous radiotherapy in the head or neck area 3. Pregnant or lactating females 4. Drug and alcohol abuse 5. Smoking > 10 cigarettes per day 6. inadequate restorative therapy or malocclusion

Design outcomes

Primary

Measure	Time frame
Probing pocket depth measured in mm using a periodontal probe at baseline, 6 months and 12 months	—

Secondary

Measure	Time frame
Bleeding on probing (yes or no) measured using a periodontal probe at baseline, 6 months and 12 months	—

Countries

Germany, Italy

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026