Comorbidities in chronic obstructive pulmonary disease. Respiratory Chronic obstructive pulmonary disease
Conditions
Interventions
Participants are allocated to one of two groups, according to the presence or the absence of comorbidities. Patients with none or only one comorbidity (n=11, Group 1) are compared to those who have tw
Sponsors
Exercise Physiology Laboratory
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. COPD diagnosis of any stage (A, B, C, D) 2. Aged 49-76 years 3. Stable condition 4. Optimal bronchodilation therapy 5. Optimal therapy of comorbidities 6. Reduced exercise capacity 7. Full compliance to the rehabilition program and recommendations
Exclusion criteria
Exclusion criteria: 1. Active or unstable cardiovascular disease (within three months: myocardial infarction, severe uncontrolled arrhythmia, symptomatic or unstable cardiovascular disease, severe heart valve disease or severe heart failure) 2. Pulmonary embolism in the last three months 3. Ischemic cardiovascular stroke or hemorrhagic stroke in the last three months 4. Non-controlled arterial hypertension 5. Large abdominal aortic aneurysm 6. Severe orthopaedic disorders 7. Severe osteoporosis 8. Any condition that does not allow the performance of aerobic exercise 9. Severe dementia 10. Severe untreated psychiatric conditions 11. Unwilling, undisciplined patient who does not comply with medical recommendations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Arterial blood gases are measured and analysed using the GEM premier 3500 blood gas analyser at baseline and after 13 weeks 2. Pulmonary function is measured using Pulmonary Function Tests (spirometry, diffusing capacity and static lung volume) at baseline and after 13 weeks 3. Dyspnea is assessed using the modified Medical research Council (MRC) scale and the COPD Assessment Test at baseline and after 13 weeks 4. Quality of Life is assessed by the St George Respiratory Questionnaire (SGRQ) at baseline and after 13 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Expiratory oxygen and carbon dioxide fractions are measured using the six minute walking test (6MWT) and standard cardiopulmonary exercise test at baseline and after 13 weeks 2. Work rate is measured using the six minute walking test (6MWT) and standard cardiopulmonary exercise test at baseline and after 13 weeks 4. Airflow is measured using the six minute walking test (6MWT) and standard cardiopulmonary exercise test at baseline and after 13 weeks 5. Cardiac frequency is measured using the six minute walking test (6MWT) and standard cardiopulmonary exercise test at baseline and after 13 weeks 6. Oxygen saturation is measured using the six minute walking test (6MWT) and standard cardiopulmonary exercise test at baseline and after 13 weeks | — |
Countries
Greece
Outcome results
None listed