Chlorhexidine mouthwash for the prevention of alveolar osteitis after oral surgery

Chlorhexidine 0.12% mouthwash for the prevention of alveolar osteitis after oral surgery: a double-blind randomized clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14646628

Enrollment

744

Registered

2016-08-16

Start date

2013-04-01

Completion date

Unknown

Last updated

2019-02-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alveolar osteitis (dry socket) Oral Health Alveolitis of jaws

Interventions

Treatment: consisted of a mouthwash with 15 mL chlorhexidine 0.12% (Oralgene® Mouthwash 0.12%, Maver, Chile) for 30 seconds, twice daily for 7 days, starting 24 hours after extraction.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with clinical indications for tooth extraction, and who presented at least one of the following risk factors for developing alveolar osteitis: 1. Tobacco smoker (consumption of = 5 cigarettes 24 hrs before extraction) 2. Previous surgical site infection (clinical diagnosis of chronic periodontitis, acute periodontal conditions, apical periodontitis, pericoronitis, fungal infections, or dental pulp gangrene) 3. Traumatic extraction (lifting a flap, use of elevators for > 4 min, and/or rotary instruments)

Exclusion criteria

Exclusion criteria: 1. Patients requiring extraction in the operating theater 2. Patients living in rural areas who manifested difficulty in returning for follow-up 3. Patients allergic to chlorhexidine 4. Patients under antimicrobial therapy, antibiotic prophylaxis, or antibiotics therapy after extraction

Design outcomes

Primary

Measure	Time frame
Positive diagnosis of alveolar osteitis was identified in patients with the following two characteristics (both variables must be present): 1. Increasing postoperative pain intensity for 4 days within and around the socket: We asked as a dichotomous variable: yes or no. (AO presents with severe pain, therefore, this variable is easily detectable) 2. Total or partial breakdown of the blood clot in the socket with or without bone exposure: like pain, this variable is easy detectable by clinical examination, the clot should completely cover the socket for proper healing The primary outcome was measured seven days after dental surgery	—

Measure

Time frame

Positive diagnosis of alveolar osteitis was identified in patients with the following two characteristics (both variables must be present): 1. Increasing postoperative pain intensity for 4 days within and around the socket: We asked as a dichotomous variable: yes or no. (AO presents with severe pain, therefore, this variable is easily detectable) 2. Total or partial breakdown of the blood clot in the socket with or without bone exposure: like pain, this variable is easy detectable by clinical examination, the clot should completely cover the socket for proper healing The primary outcome was measured seven days after dental surgery

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Countries

Chile

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026