Evaluation of topical ozonated olive oil gel on socket healing after surgical extraction of impacted molars

Evaluation of the efficacy of topical ozonated olive oil gel on socket healing after surgical extraction of impacted mandibular third molars

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14639952

Enrollment

Registered

2023-05-22

Start date

2023-04-10

Completion date

Unknown

Last updated

2023-06-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Promote bone and soft tissues healing and prevent alveolitis after surgical extraction of 3rd mandibular molar Oral Health

Interventions

This study contains two groups in a split-mouth design (control side, experimental side) in healthy adult patients. The researcher is responsible for the entire surgical procedure and

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Aged between 18 - 35 years old 2. Patients with symmetrically impacted mandibular third molar on both sides and of the same classification according to Pell & Gregory 3. Classification of general health status: ASA I (a normal, healthy, non-smoking patient with a normal body mass index) (American Society of Anesthesiologists, 2020) 4. Patients who are cooperative, have good mental ability and are committed to periodic reviews, postoperative recommendations and oral care 5. No previous surgical treatment of the target area 6. Patients with good oral health and healthy periodontal tissues

Exclusion criteria

Exclusion criteria: 1. Patients with systemic disease affecting wound healing 2. Patients with fungal lesions in oral cavity 3. Presence of a periodontal injury in the lower second molar 4. Psychologically unstable patients 5. Patients who smoke 6. Uncooperative patients 7. The presence of local pathogens around the impacted molars, such as large cysts and tumors 8. The presence of any local or general contraindications to the use of ozonted olive oil gel such as systemic diseases, G6PD deficiency, or a history of allergy, local infection, a pregnant woman or using contraceptive drugs or breastfeeding, as well as recent myocardial infarction 9. Severe anemia 10. Hyperthyroidism

Design outcomes

Primary

Measure	Time frame
1. Bone density measured using cone beam computed tomography (CBCT) imaging and ITK-SNAP software analysis at (t1) 6 weeks and (t2) 3 months after surgery 2. Soft tissue healing measured using Landry's index 7 days after surgery	—

Secondary

Measure	Time frame
1. Measurements using a periodontal probe at (t0) before surgery and (t2) 3 months after surgery 1.1. Probing depth (PD) 1.2. Gingival overgrowth (GO) 1.3. Clinical attachment level (CAL) 2. Incidence of alveolitis measured using the Blum index 7 days after surgery	—

Countries

Syria

Contacts

Public ContactZaher Jumaa

zahjm94@gmail.com+963957957823

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026