A national perioperative platform trial to improve outcomes for surgical patients (PROTECT)

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14639555

Enrollment

1000

Registered

2025-06-23

Start date

2026-03-06

Completion date

Unknown

Last updated

2026-03-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

All adult patients (=18 years) being treated within a surgical care pathway at the recruitment sites will be eligible for the trial. Surgery

Interventions

A common outcome dataset will be collected for all patients at 30 days and 90 days after surgery. In addition, longer-term outcomes may be collected using routinely collected data (for example Hospita

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: All adult patients (=18 years) being treated within a surgical care pathway at the recruitment sites will be eligible for the trial.

Exclusion criteria

Exclusion criteria: Inability or refusal to provide informed consent.

Design outcomes

Primary

Measure	Time frame
Current primary outcome(s) as of 12/01/2026: 1. Mortality at 1 year after surgery. 2. Longitudinal mortality, complications and health resource use until the closure of the PROTECT platform. 3. Complications within 30 days after surgery 4. Days alive and at home at 30 and 90 days after surgery 5. Mortality at 30 and 90 days and one year after surgery 6. Health-related quality of Life (EQ-5D-5L) at 30 and 90 days after surgery 7. Duration of primary hospital admission up to 90 days after surgery 8. Re-admission to hospital within 90 days of surgery Previous primary outcome(s): Measured using patient records: 1. Complications within 30 days after surgery 2. Days alive and at home at 30 and 90 days after surgery 3. Mortality at 30 and 90 days and 1 year after surgery 4. Health-related quality of Life (EQ-5D-5L) at 30 and 90 days after surgery 5. Duration of primary hospital admission up to 90 days after surgery 6. Re-admission to hospital within 90 days of surgery	—

Measure

Time frame

Current primary outcome(s) as of 12/01/2026: 1. Mortality at 1 year after surgery. 2. Longitudinal mortality, complications and health resource use until the closure of the PROTECT platform. 3. Complications within 30 days after surgery 4. Days alive and at home at 30 and 90 days after surgery 5. Mortality at 30 and 90 days and one year after surgery 6. Health-related quality of Life (EQ-5D-5L) at 30 and 90 days after surgery 7. Duration of primary hospital admission up to 90 days after surgery 8. Re-admission to hospital within 90 days of surgery Previous primary outcome(s): Measured using patient records: 1. Complications within 30 days after surgery 2. Days alive and at home at 30 and 90 days after surgery 3. Mortality at 30 and 90 days and 1 year after surgery 4. Health-related quality of Life (EQ-5D-5L) at 30 and 90 days after surgery 5. Duration of primary hospital admission up to 90 days after surgery 6. Re-admission to hospital within 90 days of surgery

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

England, Scotland, United Kingdom, Wales

Contacts

Public ContactPriyanthi Dias

p.dias@qmul.ac.uk+44 20 3594 0349

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Apr 3, 2026