Patients with functional dyspepsia presenting with postprandial distress syndrome, epigastric pain syndrome, or an overlap of both subtypes Digestive System
Conditions
Interventions
Intervention type: Dietary modification
Intervention description: Implementation of a six-food elimination diet excluding dairy, wheat, soy, eggs, nuts, and seafood for 4 weeks.
Duration of interventi
Sponsors
Clinic of Internal Medicine-Gastroenterology, Jessenius Faculty of Medicine in Martin, Comenius University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: For patients: 1. Age = 18 years 2. Diagnosed functional dyspepsia (Rome IV criteria) 3. Absence of acute somatic disease 4. Absence of chronic metabolic disease For healthy volunteers: 1. Age = 18 years 2. Absence of symptoms of DGBI 3. Absence of acute somatic disease 4. Absence of chronic metabolic disease
Exclusion criteria
Exclusion criteria: 1. Active malignancy (except long-term remission) 2. Severe metabolic or endocrine disease (e.g. decompensated diabetes, untreated hypothyroidism) 3. Pregnancy 4. Age < 18 years 5. Inability to attend follow-up visit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dyspeptic symptom burden assessed by validated questionnaires (PAGI-SYM, PHQ-15, PAGI-QoL,WHOQOL-BREF) at baseline and after 30 days of dietary intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| Metabolic parameters from blood, urine, and stool (assessed by Nuclear Magnetic Resonance (NMR) spectroscopy metabolomic analysis) at baseline and after 30 days of dietary intervention | — |
Countries
Slovakia
Contacts
Public ContactPeter Liptak
Outcome results
None listed