Exploring the role of the gut-kidney axis in type 1 diabetes

In individuals with type 1 diabetes, how modulation of the gut–kidney axis compared with usual gut–kidney axis function affects kidney function and the development of diabetic kidney disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14636038

Enrollment

Registered

2026-02-16

Start date

2026-01-01

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 1 diabetes mellitus and diabetic nephropathy Nutritional, Metabolic, Endocrine

Interventions

Population-based cross-sectional case-control study based on the longitudinal LatDiane cohort (Latvian Diabetic Nephropathy Study, initiated 2013). Participants: Adults with type 1 diabetes mellitus

processed and stored at -80°C for biomarker analysis. Laboratory analyses: fecal markers (calprotectin, IgA, albumin, elastase), intestinal permeability markers in serum (LPS activity, zonulin, I-FABP

Eligibility

Sex/Gender

All

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Type 1 diabetes mellitus with a duration of least 8 years 2. Available data on DKD progression in the last 3 years or more 3. Indications for colonoscopy

Exclusion criteria

Exclusion criteria: 1. eGFR <45 ml/min/1.73m2 2. Nephrotic range proteinuria (more than 3.0 g/day) 3. Hematuria in more than two consecutive urine samples 4. Histologically proven other type of glomerular disease 5. Inflammatory bowel disease 6. Coeliac disease 7. Pregnancy 8. Intestinal infection within 1 month of planned endoscopy and faecal collection 9. Gastrointestinal “alarm symptoms”: bleeding, severe weight loss, fever, abrupt onset of symptoms, anemia

Countries

Latvia

Contacts

Public ContactPolina;Jelizaveta Zalizko;Sokolovska

;

polina.zalizko@lu.lv;jelizaveta.sokolovska@lu.lv+371 (0)26876636;+371 (0)28323196

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 14, 2026