STEMI, peripheral arterial disease Circulatory System
Conditions
Interventions
Three groups will be evaluated in this study:
Group 1. 10 patients with peripheral vascular disease (PVD) undergoing elective amputation. These patients will undergo blood sampling an
Sponsors
NHS Tayside/University of Dundee
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: PVD: 1. Age between 18-70 years 2. Admitted for elective amputation for PVD 3. Able to give written informed consent STEMI: 4. Age between 18-70 years 5. Admitted to CCU for STEMI and undergone PPCI 6. Able to give written informed consent Healthy volunteers: 7. Age between 18-70 years 8. No current or previous significant medical illness 9. Able to give written informed consent
Exclusion criteria
Exclusion criteria: Healthy volunteers: 1. Positive medical history of: 1.1. Vascular diseases such as peripheral arterial disease, stroke, IHD... etc 1.2. Haematological conditions such as hypercoagulability, deep venous thrombosis... etc 1.3. Hypertension 2. Alcohol excess 3. Unable to give written informed consent STEMI/PVD: Unable to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of inflammatory cytokines taken at the time of operation in PVD group, 48-72 hours after PCI in STEMI group and at the time of assessment in healthy volunteers. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Tissue SIK levels in PVD patients at the time of surgery 2. Arterial stiffness and flow mediated dilatation in STEMI patients at 48-72 hours and in healthy volunteers at the time of assessment | — |
Countries
United Kingdom
Outcome results
None listed