Changes in cardiovascular magnetic resonance images by using magnetic resonance imaging scanner at different sites

Evaluation of the precision and accuracy of quantifications of cardiovascular magnetic resonance imaging exams

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14627679

Enrollment

820

Registered

2020-12-30

Start date

2020-08-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac disease, aortic stenosis, hypertrophic cardiomyopathy, hypertensive heart disease, aortic insufficiency, connective tissue disease of the aorta, heart failure with preserved ejection fraction, muscular dystrophy, inflammatory heart disease Circulatory System

Interventions

Healthy volunteers will have 5 cardiac MRI exams (at each different centre) and patients will each have 1 cardiac MRI exam. The study will use different imaging techniques for measurements of function

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Aged >18 years 2. Written consent 3. Healthy volunteers, patients with hemodynamic pathologies (aortic stenosis, hypertrophic cardiomyopathy, hypertensive heart disease, aortic insufficiency, and connective tissue disease of the aorta), or systemic disease (heart failure with preserved ejection fraction, muscular dystrophy, and inflammatory heart disease)

Exclusion criteria

Exclusion criteria: 1. Healthy volunteers with any known cardiac disease 2. Contraindication to cardiovascular magnetic resonance

Design outcomes

Primary

Measure	Time frame
1. Quantitatively detectable cardiovascular MRI measurement methods of function, volumes, mass, hemodynamics (forward, backward flow, regurgitation fraction, wall shear stress) and myocardial differentiation (T1, T2, T2 * times, fat-water- measurements, spectroscopy) on the MRI scanner of the different sites measured through analysis of MRI scans taken at baseline	—

Secondary

Measure	Time frame
1. Quantitatively detectable cardiovascular MRI measurement methods of the function volumes, mass, hemodynamics (forward, reverse flow, regurgitation fraction, wall shear stress) and myocardial differentiation (T1, T2, T2 * times, fat-water images, spectroscopy) for MRI investigations carried out twice in a row at the same location measured through analysis of MRI scans taken at baseline 2. Image quality measured as a semiquantitative score, as well as a calculation of contrast-to-noise and signal-to-noise ratio of the measurements on the MRI scanner at the different sites measured through analysis of MRI scans taken at baseline 3. Duration (min) of acquisition on the MRI scanner at the different sites measured through analysis of MRI scans taken at baseline	—

Measure

Time frame

1. Quantitatively detectable cardiovascular MRI measurement methods of the function volumes, mass, hemodynamics (forward, reverse flow, regurgitation fraction, wall shear stress) and myocardial differentiation (T1, T2, T2 * times, fat-water images, spectroscopy) for MRI investigations carried out twice in a row at the same location measured through analysis of MRI scans taken at baseline 2. Image quality measured as a semiquantitative score, as well as a calculation of contrast-to-noise and signal-to-noise ratio of the measurements on the MRI scanner at the different sites measured through analysis of MRI scans taken at baseline 3. Duration (min) of acquisition on the MRI scanner at the different sites measured through analysis of MRI scans taken at baseline

—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 10, 2026