Blood plasma mixed with plaster as a bone substitute placed at the site where the third molar was extracted

Calcium sulfate and plasma rich in growth factors enhance bone regeneration after extraction of the mandibular third molar: a proof of concept study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14620180

Enrollment

Registered

2021-02-11

Start date

2015-08-10

Completion date

Unknown

Last updated

2023-04-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Third molar extraction Oral Health

Interventions

An analytical, prospective, experimental and longitudinal study was performed. Sample: potential patients aged between 18 and 25 years old, male or female, with two mandibular third molars (MTM) in ve

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 18 to 25 years old 2. Two mandibular third molars in a vertical position, according to Winter's classification without active infection

Exclusion criteria

Exclusion criteria: 1. Pregnant 2. Neurological deficiency

Design outcomes

Primary

Measure	Time frame
Bone regeneration measured radiographically (Ro/BR) using immediate post-surgical periapical x-rays. Each step of the scale was numbered from 1 to 6 corresponding to a difference of 16.66%, until 100%. For the systematic evaluation of the periapical x-rays, a diagram of the alveoli was designed, dividing them into four quadrants I to IV. I and IV represent distal quadrants and II and III mesial. Each quadrant was divided into three areas A, B and C from the periphery towards the center of the alveolus.	—

Measure

Time frame

Bone regeneration measured radiographically (Ro/BR) using immediate post-surgical periapical x-rays. Each step of the scale was numbered from 1 to 6 corresponding to a difference of 16.66%, until 100%. For the systematic evaluation of the periapical x-rays, a diagram of the alveoli was designed, dividing them into four quadrants I to IV. I and IV represent distal quadrants and II and III mesial. Each quadrant was divided into three areas A, B and C from the periphery towards the center of the alveolus.

—

Secondary

Measure	Time frame
There are no secondary outcome measures.	—

Countries

Mexico

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026