Analysis of blood flow in the aorta and heart structure in heart and blood vessels diseases using magnetic resonance imaging

Assessment of the interaction between myocardial structure and hemodynamics in the ascending aorta in cardiovascular diseases with alteration of the outflow tract and the aortic valve using ultra-high-field magnetic resonance imaging

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14567789

Enrollment

150

Registered

2023-05-31

Start date

2019-05-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular diseases: aortic valve pathologies (aortic stenosis/insufficiency), hypertrophic cardiomyopathy, muscle dystrophy, heart failure with preserved ejection fraction (HFpEF), hypertension, inflammation, connective tissue disease Circulatory System

Interventions

Observational study: ultra-high-field magnetic resonance imaging 7T. The hemodynamics in the aorta as well as in the LVOT can be measured using 4D flow MRI. In addition, cardiovascular MRI (CMR) in 7T

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Healthy volunteers: 1. Aged at least 18 years Patients 1. Presence of one of the following pathologies: aortic valve pathology, hypertension, hypertrophic cardiomyopathy with narrowing of the LVOT 2. Informed consent 3. Legal capacity 4. Aged at least 18 years

Exclusion criteria

Exclusion criteria: 1. Claustrophobia 2. Any implants (e.g. pacemaker, ICD, clips, joint prostheses, >1 coronary stent) 3. Age under 18 years 4. Pregnancy, lactation 5. Rejection by patients 6. Large tattoos on the upper body (relative contraindication; individual decision together with the participant) 7. Not capable of consent 8. Placement in an institution by official or court order 9. Dependence on the investigator, trial site or sponsor

Design outcomes

Primary

Measure	Time frame
Evaluation of the hemodynamics in the left ventricular outflow tract area using 4D MRI on the 7T MRI: 1. Flow Volumes (forward and reverse flow in ml) 2. Wall shear forces in N/m² 3. Blood flow velocities in m/s	—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Germany

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026