Validating a tool to predict switch to open surgery in laparoscopic treatment for acute gallbladder inflammation: insights from multiple centers

Multicenter external validation of a nomogram predicting conversion to open cholecystectomy during laparoscopic surgery for acute calculous cholecystitis: a cross-sectional study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN14550666

Enrollment

4000

Registered

2024-05-17

Start date

2021-10-01

Completion date

Unknown

Last updated

2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute calculous cholecystitis who underwent early laparoscopic cholecystectomy Digestive System

Interventions

This is a retrospective observational study, the study does not intentionally intervene in the patients treatment measures. This study mainly involved the exposure factor - Acute calculous cholecystit

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. A first-time diagnosis of acute calculous cholecystitis confirmed by the presence of fever and/or chills, laboratory evidence of inflammation and/or abnormal liver function, and imaging confirmation of gall bladder calculus 2. Patients who underwent early laparoscopic cholecystectomy within 7 days of illness onset, according to the Tokyo Guidelines 2018 (TG18) criteria

Exclusion criteria

Exclusion criteria: 1. Patients with chronic cholecystitis 2. Acute calculous cholecystitis complicated by acute pancreatitis 3. Non-calculous acute cholecystitis, or choledocholithiasis requiring simultaneous choledocholithotomy and T-tube drainage during laparoscopic cholecystectomy

Design outcomes

Primary

Measure	Time frame
1. Demographic characteristics, such as gender, age, body mass index (BMI), hypertension status, diabetes mellitus, chronic obstructive pulmonary disease (COPD) status, and history of abdominal surgery, measured using data obtained from the Electronic Medical Record System of Huadu District People’s Hospital of Guangzhou at one time point	—

Secondary

Measure	Time frame
1. White blood cell (WBC) count, C-reactive protein (CRP), procalcitonin (PCT), platelet count, creatinine, international normalized ratio (INR), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), measured using laboratory examinations of blood and with a biochemical analyzer within 24 hours of the patient's onset of illness 2. Transabdominal ultrasound characteristics included gallbladder wall thickness, length and width, number of calculi (single or multiple), calculus location (gallbladder body or neck), calculus diameter (=3cm or <3cm), presence of gallbladder polyps, and pericholecystic effusion, measured using imaging examination with ultrasound machine within 24 hours of the patient's onset of illness	—

Measure

Time frame

1. White blood cell (WBC) count, C-reactive protein (CRP), procalcitonin (PCT), platelet count, creatinine, international normalized ratio (INR), alanine aminotransferase (ALT), and aspartate aminotransferase (AST), measured using laboratory examinations of blood and with a biochemical analyzer within 24 hours of the patient's onset of illness 2. Transabdominal ultrasound characteristics included gallbladder wall thickness, length and width, number of calculi (single or multiple), calculus location (gallbladder body or neck), calculus diameter (=3cm or <3cm), presence of gallbladder polyps, and pericholecystic effusion, measured using imaging examination with ultrasound machine within 24 hours of the patient's onset of illness

—

Countries

China

Contacts

Public ContactHongsheng Wu

crazywu2007@126.com+86 020-62935424

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026