Sleep apnoea Respiratory Sleep apnoea
Conditions
Interventions
The total duration of participants in this research study will be 4 months. Participants will be recruited from sleep clinics at the Sleep Disorder’s Centre, Guy’s Hospital. Participants will have an
Sponsors
King’s College London
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. Male patients 2. Untreated mild OSA (AHI>5events/hour and 30events/hour) 3. Excessive sleepiness (ESS>9) 4. Aged 18- 65 years
Exclusion criteria
Exclusion criteria: 1. Female patients 2. Patients with other sleep disorders 3. Current or past neurological or psychiatric disease 4. Undertaking neuropharmacological treatment 5. History of alcohol or recreational drug abuse 6. Major organ failure 7. Professional drivers/shift workers 8. Unable to have MRI scan (e.g. too heavy (>200Kg) or who have ferromagnetic implants) 9. Inability to comprehend what is proposed 10. Inability to travel to the research sites
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of neuroinflammation and discrete changes in brain morphology, physiology and cognition will be measured via MRI, PET-MRI imaging and cognitive testing (CANTAB battery) at baseline and after 3 months of CPAP treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Genetic analysis and linkage to clinical and neuroimaging data will be measured using biological samples (blood or saliva) which will be analysed and stored in the BioResource for Mental and Neurological Health at baseline and 3 months after CPAP treatment. | — |
Countries
United Kingdom
Outcome results
None listed