Specialty: Musculoskeletal disorders, Primary sub-specialty: Other
Conditions
Interventions
All patients in this feasibility trial will have their Vitamin D level checked before surgery, on the day of surgery and at 6 months after surgery. Those patients who, before their operation, are foun
Sponsors
Northumbria Healthcare NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients scheduled for primary total hip or knee arthroplasty 2. Aged over 18 3. Presenting at a participating trial site
Exclusion criteria
Exclusion criteria: 1. Lack of mental capacity to understand/comply with study procedures 2. Revision surgery 3. Known contraindication to Vitamin D treatment, e.g. previous diagnosis of sarcoidosis, primary hyperparathyroidism or other hypercalcaemic disorders, allergy 4. Renal impairment with eGFR <30 mL/minute 5. Already taking a Vitamin D supplement
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain and function is measured using the Oxford hip or knee score, collected by written questionnaire at baseline and 6 months 2. Health-related quality of life is measured using the EQ-5D collected by written questionnaire at baseline and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Length of hospital stay is collected from medical notes at endline 2. Medical complications including superficial and deep infection are collected from medical notes at endline 3. Readmission rates within 30 days of primary surgery are collected from medical notes at endline 4. Return to theatre rate within 30 days is collected from medical notes at endline 5. Mortality at 90-days is collected from medical notes at endline | — |
Countries
England, United Kingdom
Outcome results
None listed