Precision exercise in obese children with bronchial asthma

Precision exercise prescription for obese children with bronchial asthma: a dose-dependent study on adiposity biomarkers, body composition, and respiratory efficiency

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN14530971

Enrollment

Registered

2025-11-08

Start date

2023-09-17

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity and bronchial asthma Nutritional, Metabolic, Endocrine

Interventions

This investigation recruited 72 obese children with a confirmed bronchial asthma diagnosis. Randomization Method: The study employed permuted block randomization with blocks of varying sizes. Alloca

Eligibility

Sex/Gender

All

Age

8 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Age of 8-18 years 2. Body mass index ranging from 30 to 35 kg/m2 3. Verified asthma diagnosis per the Global Initiative for Asthma (GINA) 4. criteria 5. Moderate Onset 6. Clinically Stable 7. Maintained medication dosages in the past three months 8. Free of lower limb or spinal deformities 9. Not engaging in regular exercise regimens in the past six months

Exclusion criteria

Exclusion criteria: 1. Exacerbated asthma symptoms 2. Chronic lung comorbidities 3. Cardiovascular or musculoskeletal conditions expected to hinder the training

Design outcomes

Primary

Measure	Time frame
The following adiposity and inflammatory biomarkers were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits, pre- and post-training: 1. Serum leptin concentration 2. Serum total adiponectin 3. Serum high-molecular-weight adiponectin 4. Serum resistin concentration 5. Systemic interleukin-6 6. High-sensitivity C-reactive protein The following body composition variables were measured using a bioelectrical impedance analysis device, except where stated, pre- and post-training: 7. Body fat percentage 8. Total body fat mass 9. Fat-free mass 10. Total body water 11. Basal metabolic rate The following respiratory function variables were measured using a calibrated spirometer pre- and post-training: 12. Forced expiratory volume in one second (FEV#) 13. Forced vital capacity (FVC) 14. Forced Expiratory Volume in One Second (FEV1) / Forced Vital Capacity (FVC) Ratio	—

Measure

Time frame

The following adiposity and inflammatory biomarkers were measured using commercially available enzyme-linked immunosorbent assay (ELISA) kits, pre- and post-training: 1. Serum leptin concentration 2. Serum total adiponectin 3. Serum high-molecular-weight adiponectin 4. Serum resistin concentration 5. Systemic interleukin-6 6. High-sensitivity C-reactive protein The following body composition variables were measured using a bioelectrical impedance analysis device, except where stated, pre- and post-training: 7. Body fat percentage 8. Total body fat mass 9. Fat-free mass 10. Total body water 11. Basal metabolic rate The following respiratory function variables were measured using a calibrated spirometer pre- and post-training: 12. Forced expiratory volume in one second (FEV#) 13. Forced vital capacity (FVC) 14. Forced Expiratory Volume in One Second (FEV1) / Forced Vital Capacity (FVC) Ratio

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

Saudi Arabia

Contacts

Public ContactRagab Elnaggar

r.elnaggar@psau.edu.sa+96611588631

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026