Asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and post-COVID-19 infection Respiratory Asthma, chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and post-COVID-19 infection
Conditions
Interventions
Four groups of patients will be identified from those attending the respiratory outpatient clinic: those with asthma, COPD, ILD and post-COVID-19 infection.
Patients will be due to have full pulmonar
a posterio-anterior image and a lateral view. Patients will be asked to breathe normally and then take a deeper breath over a 10-second period (following a standardised protocol) while these images ar
Sponsors
Royal Liverpool University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Undergoing PFTs in the next 6 months for clinical reasons 2. Asthma group: 2.1. A clinical history in keeping with asthma 2.2. Physiological evidence of asthma (defined as post bronchodilator reversibility, variable FEV1 over time or a previous positive bronchial challenge test) 3. COPD group: 3.1. A clinical history in keeping with COPD 3.2. Physiological evidence of COPD (FEV1/FVC ratio of <0.7) 4. ILD group: 4.1. A clinical history in keeping with ILD 4.2. HRCT findings in keeping with ILD 5. Post-COVID-19 group: 5.1. Serologically confirmed COVID-19 infection 5.2. Chest X-ray or CT findings in keeping with COVID-19 5.3. At least 12 weeks post-recovery from acute COVID-19 6. Fluent spoken English - to ensure a comprehensive understanding of the research project and their proposed involvement 7. Able to achieve positioning for a PA and lateral chest X-ray for a 30-second period
Exclusion criteria
Exclusion criteria: 1. Unable to provide informed consent 2. Significant other respiratory co-morbidities as judged by study doctor 3. Recent/ongoing exacerbation of airways disease or interstitial lung disease within the last 4 weeks (from the recruitment date). 4. Women of child bearing age; a positive pregnancy test or refusal of pregnancy test (a negative pregnancy test on the day of DCR is a requirement). 5. Significant research-related radiation exposure in the last 12 months prior to consent (from participation in previous studies involving radiation exposure, with a research dose constraint of 0.4 mSv).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient acceptability score as measured by a Visual analogue scale (VAS) completed by participants post dynamic chest X-ray | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Number of patients recruited to the study recorded per month 2. Number of days from patient consent to performing DCR, recorded post-dynamic chest X-ray 3. Time (in minutes) required for DCR imaging process (defined as time from arrival at DCR suite to image acquisition) completed post-dynamic chest X-ray 4. Lung volume measurements (in Litres) as derived by dynamic chest radiography (Maximal Inspiratory Volume (MIV), End Expiratory Volume (EEV), Vital Capacity (MIV-EEV)) measured at the point of dynamic chest imaging 5. Lung volume measurements (total lung capacity (TLC), residual volume (RV), forced vital capacity (FVC), residual volume (RV)) in litres recorded at the point of pulmonary function testing | — |
Countries
England, United Kingdom
Outcome results
None listed