Keratosis pilaris Skin and Connective Tissue Diseases
Conditions
Interventions
In this experiment, the randomization method of drawing lots was employed. After all patients were numbered, group numbers were randomly drawn to assign them to different groups for therapeutic resear
Sponsors
Beijing Technology & Business University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Chinese participants aged 18 to 55 years, who meet the diagnostic criteria for keratosis pilaris. 2. Willing to undergo treatment and complete the course, attend follow-up visits on schedule for photography, and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with severe organic diseases of important organs such as cardiovascular and cerebrovascular diseases, diabetes, liver and kidney diseases, bleeding disorders, and severe primary hematologic diseases, as well as patients with mental illness. 2. Patients allergic to mandelic acid or other test drugs. 3. Patients with active viral diseases such as herpes simplex or warts at the treatment site, or those who have undergone cryotherapy, radiotherapy, phototherapy, or surgery in the past six months. 4. Patients who have taken oral corticosteroids within the past three months. 5. Patients with immunodeficiency diseases or a history of keloid formation. 6. Patients who are currently participating in or have participated in other clinical studies/treatments within the past three months. 7. Women who are planning to conceive, pregnant, or breastfeeding. 8. Patients whose medical history, physical examination, and laboratory tests can rule out keratosis pilaris secondary to other diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of follicular papules was recorded by dermatoscope, and the improvement index of follicular papules was calculated at baseline, 7,14,21,and 28 day. | — |
Secondary
| Measure | Time frame |
|---|---|
| The skin roughness (SEr), smoothness (SEsm), and scaling index (SEsc) were measured using the skin microscope Visioscan® VC98 at baseline, 7,14,21,and 28 day. | — |
Countries
China
Contacts
Public ContactHong Meng
Outcome results
None listed