Vertebral fractures, including those in patients with osteoporosis Musculoskeletal Diseases 1. Osteoporosis 2. Vertebral fractures
Conditions
Interventions
Patients with a diagnosed or suspected diagnosis of an acute vertebral fragility fracture will be invited to participate in the study. Data collection will be conducted on admission, at discharge from
Sponsors
Nottingham University Hospitals NHS Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Adults aged 50 years and over 2. Admitted to hospital with either a low trauma or atraumatic vertebral fragility fracture or suspected vertebral fragility fracture pending radiology investigation. A low trauma fracture is a fracture sustained after a fall from a standing height or less. A diagnosis of vertebral fracture is made radiologically (i.e. x-ray imaging, computerised tomography (CT), magnetic resonance imaging (MRI) of the spine) or bone (scintigraphy) scan. 3. While in hospital was diagnosed with a vertebral fragility fracture unrelated to their index admission
Exclusion criteria
Exclusion criteria: 1. Patients without a vertebral fracture 2. Patients admitted electively to hospital for management of their vertebral fracture 3. Patients transferred from another hospital 4. Vertebral fracture sustained as a result of a high impact injury, e.g. road traffic accident, fall down a flight of stairs, etc. 5. Patients presenting with a concomitant fracture elsewhere 6. Patients admitted to hospital under a major trauma pathway 7. Patients with known or suspected malignancy 8. Patients with known primary bone disorder (e.g Paget’s disease) other than osteoporosis 9. Patients terminally ill or moribund
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Pain is measured using an 11 point numeric rating scale at baseline (on admission to hospital), on discharge from hospital and at 6 months 2. Mood is measured using the Geriatric Depression Scale at baseline (on admission to hospital) and at 6 months 3. Cognition is measured using the Montreal Cognitive Assessment at baseline (on admission to hospital) and at 6 months 4. Disability is measured using the Elderly Mobility Scale, Barthel Index, Nottingham Extended Activities of Daily Living and Roland Morris Disability Questionnaire at baseline (on admission to hospital) and at 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hospital inpatient mortality and overall mortality are measured by analysing healthcare records at 6 months 2. Hospital related outcomes measured by analysing hospital paper and electronic healthcare records on patients discharge - length of stay, discharge destination/changes in residency, hospital related complication (hospital acquired infection, pressure sore, venous thromboembolic event, delirium and neurological impairment) 3. Quality of life post-hospitalisation for vertebral fractures is measured using the EQ-5D measured at 6 months 4. Healthcare resource utilisation after hospital discharge is measured through self or proxy reporting at 6 months | — |
Countries
United Kingdom
Outcome results
None listed