Multiple sclerosis Nervous System Diseases Multiple sclerosis
Conditions
Interventions
Participants are randomly allocated to one of two groups.
Virtual reality (VR) group: Patients participate in 12 sessions of CAREN VR over six weeks, with a total of 30 minutes of balance training du
Sponsors
Sheba Medical Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Diagnosis of definite relapsing-remitting MS according to the revised McDonald criteria 2010 2. Aged between 25 and 55 years 3. Moderate neurological disability as scored by the expanded disability status scale (EDSS), ranging from 3.0 to 6.0 inclusive with a pyramidal functional score of at least 3
Exclusion criteria
Exclusion criteria: 1. MS clinical relapse or treatment with corticosteroid therapy within 6-months prior to examination 2. Patients experiencing major depression or cognitive decline 3. Orthopedic disorders that could negatively affect balance 4. Pregnancy 5. Blurred vision 6. Cardiovascular disorders
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Center of pressure (CoP) trajectories are measuring using posturography measurements taken from the Zebris FDM-T Treadmill data at baseline and 6 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Stability is measured using the Functional Reach Test (FRT) at baseline and 6 weeks 2. Balance is measured using the Berg Balance Test (BBS) at baseline and 6 weeks 3. Ability to change directions while stepping is measured using the Four Square Step Test (FSST) at baseline and 6 weeks 4. Fear of falling is measured using the Falls Efficacy Scale International (FES-I) at baseline and 6 weeks | — |
Countries
Israel
Outcome results
None listed