Intraocular pressure after bevacizumab intravitreal injection Eye Diseases
Conditions
Interventions
200 patients were enrolled and underwent preoperative ophthalmologic evaluation, with anamnestic data collection. They were randomized to the different study arms (40 eyes injected for each study arm)
2. Topical anesthetic and 5% povidone-iodine instillation in the eye to be injected
3. Intravitreal injection
4. Application of gentle pressure using cotton swab for 5 seconds to avoid vitreous reflux
5. Instillation of povidone-iodine 0.5%, Ofloxacin (Oftaquix®) and Netilmicin- Dexamethasone (Netildex®).
Arm
Arm C was injected by pre-injection digital ocular massage technique (intravitreal injection performed according to the standard protocol, preceded by digital ocular massage for 5 minutes)
Arm D was injected by post- injection scleral indentation technique (intravitreal injection performed according to the standard protocol, with addition of post- intravitreal injection scleral indentat
Arm E was injected by post- injection digital ocular massage technique (intravitreal injection performed according to the standard protocol, followed by digital ocular massage).
All subjects underwe
Sponsors
Eye Clinic, Univertsity of Turin
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 18 to 99 years old 2. Indication for intravitreal injection of anti-VEGF drug (bevacizumab) 3. Absence of contraindications to the execution of intravitreal injection (systemic or local conditions that make the injective treatment not indicated) 4. Possibility of expressing informed consent to participation in the study
Exclusion criteria
Exclusion criteria: 1. Prior intravitreal injection into the eye being studied in the previous month 2. Prior history of endophthalmitis following intravitreal injection 3. Prior intravitreal steroid injection in the previous 6 months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage of post- intravitreal injection IOP spikes with IOP =40 mmHg in study arms measured using Goldmann applanation tonometry 10 min before and 10 min after injection 2. Phakia/pseudophakia status 3. Previous diagnosis of glaucoma 4. Ophthalmic pathology for which indication was given to intravitreal injection 5. The percentage of adverse events was also evaluated | — |
Primary
| Measure | Time frame |
|---|---|
| Variation of the post-injection IOP with the different injection techniques measured using Goldmann applanation tonometry 10 min before and 10 min after injection. | — |
Countries
Italy
Outcome results
None listed