Cardiovascular disease, dementia, cancer Other
Conditions
Interventions
Record-level electronic health data will be requested from NHS England and equivalent registries in Scotland & Wales. These records will be used to follow up on the original SEARCH cohort for an exten
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Participants were part of the original SEARCH cohort (randomised between 1998 and 2001). They were between 18 and 75 years old when invited to participate. Participants had to fulfil all of the following criteria: 1. History of prior myocardial infarction 2. Current use of a statin or clear indication for statin therapy 3. No clear indication for folic acid 4. No clear contraindications to the study treatments 5. No other medical problem For inclusion into the legacy cohort, participants had to be residents of the UK
Exclusion criteria
Exclusion criteria: 1. Participants who have opted out of having their data provided by NHS England 2. Participants who have read the privacy notice and have decided that they do not want their data used in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first planned analyses will be based on at least 15 years’ follow-up from trial initiation with further analyses planned at approximately 5 yearly intervals based on ongoing linkage to NHS records. Appropriate analysis methods will be used to compare the risk ratios for first occurrence post-randomisation of each outcome of interest (dementia, stroke, all major cardiovascular disorders, other vascular disease complications, myopathies, heart failure, renal impairment, other health and care outcomes and death) between both allocated treatment groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| There are no secondary outcome measures | — |
Countries
England, United Kingdom
Contacts
Public ContactMichelle Nunn
Outcome results
None listed